Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype.
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Summary
Neocortical neurofibrillary tangle densities were substantially correlated with dementia severity, and to a greater degree than was true for senile plaque densities, and the order of the strength of relationships between densities of histologic markers and dementia severity in AD is neuroFibrillary tangles greater than cored senile plaques greater than total senile Plaques.
- Type
- article
- Published
- 1998-03-01
- Cited by
- 670
- References
- 94
- OpenAlex
- https://openalex.org/W1972340735
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45532881
Keywords
Senile plaques, Neurofibrillary tangle, Dementia, Alzheimer's disease, Pathology
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- Longitudinal Driving Performance in Early‐Stage Dementia of the Alzheimer Type
- Prevalence and impact of cerebrovascular pathology in Alzheimer's disease and parkinsonism
- Clinicopathological analysis of dementia disorders in the elderly – An update
- Detection of PCC functional connectivity characteristics in resting-state fMRI in mild Alzheimer's disease.
- Apport de l'analyse multidisciplinaire dans la compréhension des mécanismes physiopathologiques des démences
- Neuropathologic correlates of trial-related instruments for Alzheimer's disease.
- Neuropathology of Cognitively Normal Elderly
- Intraindividual Variability as a Correlate of White Matter Decline
- Using Pittsburgh Compound B for In Vivo PET Imaging of Fibrillar Amyloid-Beta
- Age-related mild cognitive deficit: a ready-to-use concept?
- Neurocognitive implications of diabetes on dementia as measured by an extensive neuropsychological battery.
- Analyzing dendritic spine pathology in Alzheimer’s disease: problems and opportunities
- Hippocampal Dysfunction in the 3xTgAD Mouse Model of Alzheimer's Disease
- Central Adiposity and Cortical Thickness in Midlife
- The Interaction of APOE Genotype by Age in Amnestic Mild Cognitive Impairment: A Voxel-Based Morphometric Study
- The cellular mechanism underlying neuronal changes in Alzheimer's disease
- Cardiorespiratory fitness and white matter integrity in Alzheimer’s disease
- The Pathology of “Vascular Dementia”: A Critical Update
- The Diagnosis of Alzheimer's Disease
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