Effects of circulating tumor necrosis factor on the neuronal activity and expression of the genes encoding the tumor necrosis factor receptors (p55 and p75) in the rat brain: a view from the blood-brain barrier.
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Summary
The cellular distribution of both receptor messenger RNAs across the rat brain under basal conditions and in response to systemic injection with the bacterial endotoxin lipopolysaccharide and recombinant rat tumor necrosis factor-alpha are described to provide the evidence that p55 is the most abundant tumor Necrosis factor receptor in the central nervous system and is expressed in barrier-associated structures.
- Type
- article
- Published
- 1999-08-01
- Cited by
- 279
- References
- 43
- OpenAlex
- https://openalex.org/W1971446180
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5665636
Keywords
Tumor necrosis factor alpha, Biology, Proinflammatory cytokine, Receptor, Cytokine
References
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- Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection.
- A novel domain within the 55 kd TNF receptor signals cell death.
Cited by
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- Science review: The brain in sepsis – culprit and victim
- Peripheral lipopolysaccharide induces apoptosis in the murine olfactory bulb.
- The association between seizure predisposition and inflammation in a rat model of fatty liver disease
- Talking to the Brain at the Blood-Brain Barrier through Inflammation-Induced Prostaglandin E2
- MECHANISMS OF THE NEURAL AND BEHAVIORAL EFFECTS OF STAPHYLOCOCCAL ENTEROTOXIN A AFTER ACUTE AND REPEATED EXPOSURE: THE ROLE OF TUMOR NECROSIS FACTOR-ALPHA
- Neuronale Aktivierung im Nucleus Tractus Solitarius nach intrajejunaler und systemischer Lipopolysaccharidgabe im Dünndarm der Ratte
- Rapid Improvement of Chronic Stroke Deficits after Perispinal Etanercept
- Central Nervous System and Innate Immune Mechanisms for Inflammation- and Cancer-induced Anorexia
- Neurochemical and behavioral responses to inflammatory immune stressors.
- Inflammation-Induced Gene Expression in Brain and Adrenal Gland
- Development of rodent in vivo models: Neuroinflammation and neurodegeneration relevant to Alzheimer's disease.
- Regulation of ABC Efflux Transporters at Blood-Brain Barrier in Health and Neurological Disorders
- Caractérisation de l'apoptose observée dans le système limbique après une ischémie myocardique transitoire chez le rat
- Papel pró-inflamatório do receptor CD40 em ilhotas pancreáticas
- Tumor necrosis factor‐α at the crossroads of neuronal life and death during HIV‐associated dementia
- The Cholinergic Anti-inflammatory Pathway: A Missing Link in Neuroimmunomodulation
- Selective Oestrogen Receptor Modulators Decrease the Inflammatory Response of Glial Cells
- Peripheral inflammation remotely triggers global gene expression changes in the brain
- Signaling the brain in systemic inflammation: the role of perivascular cells.
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