Simplistic pathways or complex networks?
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Summary
It is argued studies must be conducted on a network level to assess the impact of genomic alterations on the structure of signaling networks and on the ability of cells to accurately translate environmental cues into phenotypic changes.
- Type
- review
- Published
- 2010-02-01
- Cited by
- 41
- References
- 83
- OpenAlex
- https://openalex.org/W1970957413
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1740597
Keywords
Biology, Context (archaeology), Signal transduction, Computational biology, Phenotype
References
- Signaling networks assembled by oncogenic EGFR and c-Met
- Improved classification of breast cancer by analysis of genetic alterations and gene expression profiling
- Coactivation of Receptor Tyrosine Kinases Affects the Response of Tumor Cells to Targeted Therapies
- Evidence that fold-change, and not absolute level, of β-catenin dictates Wnt signaling
- Population context determines cell-to-cell variability in endocytosis and virus infection
- A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans
- Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma
- Therapeutically Targeting ErbB3: A Key Node in Ligand-Induced Activation of the ErbB Receptor–PI3K Axis
- A systems-biology analysis of feedback inhibition in the Sho1 osmotic-stress-response pathway.
- Time-resolved Mass Spectrometry of Tyrosine Phosphorylation Sites in the Epidermal Growth Factor Receptor Signaling Network Reveals Dynamic Modules*S
- A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor
- Bayesian Network Approach to Cell Signaling Pathway Modeling
- Reading protein modifications with interaction domains
- A Systems Model of Signaling Identifies a Molecular Basis Set for Cytokine-Induced Apoptosis
- Modeling a Snap-Action, Variable-Delay Switch Controlling Extrinsic Cell Death
- MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
- Clinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or Amplification
- A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases
- Correction: Evolution of Phosphoregulation: Comparison of Phosphorylation Patterns across Yeast Species
- A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling
Cited by
- Modeling signaling networks using high-throughput phospho-proteomics.
- CellNOptR: a flexible toolkit to train protein signaling networks to data using multiple logic formalisms
- Empirical inference of circuitry and plasticity in a kinase signaling network
- Gene and Gene-Set Analysis for Genome-Wide Association Studies
- Biological signalling activity measurements using mass spectrometry.
- Systems biology and the integration of mechanistic explanation and mathematical explanation.
- Network medicine strikes a blow against breast cancer.
- Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling
- Spatial Phosphoprotein Profiling Reveals a Compartmentalized Extracellular Signal-regulated Kinase Switch Governing Neurite Growth and Retraction*
- The dawn of a new era in cell signalling research
- Ovarian cancer evolution through stochastic genome alterations: defining the genomic role in ovarian cancer
- NMR Analysis of a Stress Response Metabolic Signaling Network
- Personalized Network‐Based Treatments in Oncology
- A Directed Protein Interaction Network for Investigating Intracellular Signal Transduction
- PROTEINCHALLENGE: crowd sourcing in proteomics analysis and software development.
- Defining pluripotent stem cells through quantitative proteomic analysis
- State–time spectrum of signal transduction logic models
- Machine Learning Prediction of Cancer Cell Sensitivity to Drugs Based on Genomic and Chemical Properties
- Mapping the human phosphatome on growth pathways
- Phospho.ELM: a database of phosphorylation sites—update 2011
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