A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2–q13.1
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Summary
Genomewide linkage analysis of a Japanese family with autosomal dominant parkinsonism, which exhibits clinical features compatible with those of common Parkinson's disease, yielded Zmax LOD scores of 14.2 and 24.9 at D12S345, respectively, strongly supporting the mapping of the parkinsonist locus in this family to 12p11.23–q13.11.
- Type
- article
- Published
- 2002-03-01
- Cited by
- 720
- References
- 27
- OpenAlex
- https://openalex.org/W1970687029
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10360790
Keywords
Penetrance, Locus (genetics), Genetics, Haplotype, Genetic linkage
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Cited by
- Molecular Pathways of Neurodegeneration in Parkinson's Disease
- Parkinson's disease and LRRK2: Frequency of a common mutation in U.S. movement disorder clinics
- Parkin mutations in familial and sporadic Parkinson's disease among Indians.
- LRRK2 mutations in Spanish patients with Parkinson disease: frequency, clinical features, and incomplete penetrance.
- Exploring the relationship between essential tremor and Parkinson's disease.
- Kinase signaling pathways as potential targets in the treatment of Parkinson’s disease
- Genetic factors involved in the pathogenesis of Parkinson's disease.
- LRRK2 is expressed in B-2 but not in B-1 B cells, and downregulated by cellular activation.
- Genetic characteristics of leucine-rich repeat kinase 2 (LRRK2) associated Parkinson's disease.
- Biomarkers for the diagnosis and management of Parkinson's disease.
- Evidence that the LRRK2 ROC domain Parkinson's disease‐associated mutants A1442P and R1441C exhibit increased intracellular degradation
- Heterogeneity of Leucine-Rich Repeat Kinase 2 Mutations: Genetics, Mechanisms and Therapeutic Implications
- LRRK2: An Emerging New Molecule in the Enteric Neuronal System That Quantitatively Regulates Neuronal Peptides and IgA in the Gut
- Genetic Forms of Parkinson's Disease
- T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease
- Interferon gamma induces leucine-rich repeat kinase LRRK2 via extracellular signal-regulated kinase ERK5
- Role of glutathione s-transferase pi in neuronal protection under oxidative stress and proteasome inhibition relevance to Parkinson’s disease
- Elucidating the functional interplay between Parkinson’s disease-related proteins and the mitochondrion
- Molecular genetic findings in LRRK2 American, Canadian and German families.
- Genetic studies of LRRK2 and PINK1 in Parkinson's disease
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