The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases
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Summary
Proof-of-concept clinical trials have shown that low-dose interleukin-2 specifically expands and activates TReg cell populations and thus can control autoimmune diseases and inflammation.
- Type
- review
- Published
- 2015-04-17
- Cited by
- 617
- References
- 128
- OpenAlex
- https://openalex.org/W1970246068
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13652674
Keywords
Immunology, Inflammation, Effector, Immune system, Disease
References
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- In vivo administration of purified human interleukin 2. I. Half-life and immunologic effects of the Jurkat cell line-derived interleukin 2.
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- Recovery from autoimmunity of MRL/lpr mice after infection with an interleukin-2/vaccinia recombinant virus
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- T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development.
- A low IL-2R signaling threshold supports the development and homeostasis of T regulatory cells
- Massive expansion of regulatory T-cells following interleukin 2 treatment during a phase I-II dendritic cell-based immunotherapy of metastatic renal cancer.
- Interleukin-2 inhibits germinal center formation by limiting T follicular helper differentiation
Cited by
- Approaches in Immunotherapy, Regenerative Medicine, and Bioengineering for Type 1 Diabetes
- Hippo kinases Mst1 and Mst2 sense and amplify IL-2R–STAT5 signaling in regulatory T cells to establish stable regulatory activity
- Exploring cell-based tolerance strategies for hand and face transplantation
- Functional Modulation of Regulatory T Cells by IL-2
- Interleukin-2: Biology, Design and Application.
- T follicular helper (Tfh) cells in lupus: Activation and involvement in SLE pathogenesis
- Novel immunotherapies for immune-mediated haemolytic anaemia in dogs and people.
- Therapeutic potential of low-dose IL-2 in a chronic GVHD patient by in vivo expansion of regulatory T cells.
- IL-15 and T cell stemness in T cell-based cancer immunotherapy
- In vivo activation of Treg cells with a CD28 superagonist prevents and ameliorates chronic destructive arthritis in mice
- IL-7R signaling in regulatory T cells maintains peripheral and allograft tolerance in mice
- Regulatory T Cells Orchestrate Similar Immune Evasion of Fetuses and Tumors in Mice
- IL-2 / α-IL-2 Complex Treatment Cannot Be Substituted for the Adoptive Transfer of Regulatory T cells to Promote Bone Marrow Engraftment
- To serve and to protect: the role of decidual innate immune cells on human pregnancy
- Antigen-Specific Regulatory T Cells and Low Dose of IL-2 in Treatment of Type 1 Diabetes
- Re-examining the nature and function of self-reactive T cells
- Regulatory T Cells in Autoimmune Diabetes: Mechanisms of Action and Translational Potential.
- Modeling the effect of exogenous Interleukin 7 in HIV patients under antiretroviral therapy with low immune reconstitution
- O2‐07‐03: Regulatory T Cells Delay Disease Progression in Alzheimer's‐Like Pathology
- Discovering potential drug-targets for personalized treatment of autoimmune disorders - what we learn from epidermolysis bullosa acquisita
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