Linkage disequilibrium maps and association mapping.

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Summary

The causal chain between a gene and its effect on disease susceptibility cannot be understood until the effect has been localized in the DNA sequence, and polymorphisms incorporated in the HapMap Project have made linkage disequilibrium the most powerful tool for localization.

Type
review
Published
2005-06-01
Cited by
53
References
35
Access
Open access

Keywords

Linkage disequilibrium, International HapMap Project, Association mapping, Genetic association, Genetics

References

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