Linkage disequilibrium maps and association mapping.
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Summary
The causal chain between a gene and its effect on disease susceptibility cannot be understood until the effect has been localized in the DNA sequence, and polymorphisms incorporated in the HapMap Project have made linkage disequilibrium the most powerful tool for localization.
- Type
- review
- Published
- 2005-06-01
- Cited by
- 53
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W1969997927
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11499421
Keywords
Linkage disequilibrium, International HapMap Project, Association mapping, Genetic association, Genetics
References
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- THE LINEAR ARRANGEMENT OF SIX SEX-LINKED FACTORS IN DROSOPHILA, AS SHOWN BY THEIR MODE OF ASSOCIATION
- Does haplotype diversity predict power for association mapping of disease susceptibility?
Cited by
- Mapping the new frontier: complex genetic disorders.
- Characterizing the Flax Core Collection for Earliness and Canopy Traits
- IDENTIFIKASI MARKA GEN KETAHANAN HAWAR DAUN BAKTERI PADA GALUR PADI INTRODUKSI DAN GALUR DIHAPLOID
- The promise of composite likelihood methods for addressing computationally intensive challenges.
- Host susceptibility to persistent hepatitis B virus infection.
- Genética y genómica de la hipertensión arterial: una actualización
- Evolutionary genetic bases of longevity and senescence.
- Investigating the genetic basis of cranial cruciate ligament rupture in the Newfoundland dog
- Optimizing Experimental Design in Genetics
- Microarray technology in obstetrics and gynecology: A guide for clinicians
- Association Between Human Polymorphic DNA Markers and Hypoxia Adaptation in Sherpa Detected by a Preliminary Genome Scan
- Magnetic resonance imaging as a tool for in vivo and ex vivo anatomical phenotyping in experimental genetic models
- Genetic Variability of Major Inflammatory Mediators Has No Impact on the Outcome of Kidney Transplantation
- Nutrigenomics
- Association mapping of quantitative trait loci for carcass and meat quality traits at the central part of chromosome 2 in Italian Large White pigs.
- Analytical Approaches and Population Types for Finding and Utilizing QTL in Complex Plant Populations
- Mechanisms of Disease: genetics of rheumatoid arthritis—ethnic differences in disease-associated genes
- Advances in the Research of Strategies and Methods for Analyzing Complex Traits
- A novel method to express SNP‐based genetic heterogeneity, Ψ, and its use to measure linkage disequilibrium for multiple SNPs, Dg, and to estimate absolute maximum of haplotype frequency
- Perils in the Use of Linkage Disequilibrium for Fine Gene Mapping: Simple Insights from Population Genetics
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