Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer
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Summary
The correlation of SPHK1 with a poor prognosis as well as its high expression among ER negative tumors are in line with the antiapoptotic and proliferative properties of its product sphingosine-1-phosphate.
- Type
- article
- Published
- 2008-11-01
- Cited by
- 314
- References
- 36
- OpenAlex
- https://openalex.org/W1969996654
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10767067
Keywords
Sphingolipid, Sphingosine kinase 1, Sphingosine, Ceramide, Biology
References
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- Accumulation of Glucosylceramides in Multidrug-resistant Cancer Cells*
- Sphingosine kinase-1 – a potential therapeutic target in cancer
- Laser microdissection and microarray analysis of breast tumors reveal ER-α related genes and pathways
- Sphingosine kinase 1 regulates pro-inflammatory responses triggered by TNFalpha in primary human monocytes.
- Ceramide glycosylation potentiates cellular multidrug resistance
- Sphingosine Kinase-1 Expression Correlates With Poor Survival of Patients With Glioblastoma Multiforme: Roles of Sphingosine Kinase Isoforms in Growth of Glioblastoma Cell Lines
- A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death.
- Sphingosine-1-phosphate stimulates motility and invasiveness of human glioblastoma multiforme cells.
- Estrogen-receptor status and outcomes of modern chemotherapy for patients with node-positive breast cancer.
Cited by
- Prediction of human protein–protein interaction by a mixed Bayesian model and its application to exploring underlying cancer-related pathway crosstalk
- Gene expression profiling of luminal B breast cancers reveals NHERF1 as a new marker of endocrine resistance
- Role of Sphk1 in the malignant transformation of breast epithelial cells and breast cancer progression.
- Sphingosine kinase 2 deficiency increases proliferation and migration of renal mouse mesangial cells and fibroblasts
- Immunohistochemical detection of sphingosine-1-phosphate and sphingosine kinase-1 in human tissue samples.
- Sphingosine kinase/sphingosine 1-phosphate signaling in cancer therapeutics and drug resistance.
- Effet de l’expression de la GD3 synthétase sur la progression et l’agressivité du cancer du sein
- Therapeutic potential of targeting SK1 in human cancers.
- Sphingolipids and response to chemotherapy.
- Role of Ceramide Kinase in Breast Cancer Progression
- Sphingolipid metabolizing enzymes as novel therapeutic targets.
- Sphingosine Kinases in B-lineage Acute Lymphoblastic Leukaemia
- Signaling mechanisms of resistance to EGFR- and Anti-Angiogenic Inhibitors cancer.
- Sphingosine kinase 1 as an anticancer therapeutic target
- Sphingosine‐1‐phosphate antibodies as potential agents in the treatment of cancer and age‐related macular degeneration
- Loss of sphingosine kinase‐1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin‐induced DNA damage
- The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer
- Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases
- Neutralizing S1P inhibits intratumoral hypoxia, induces vascular remodelling and sensitizes to chemotherapy in prostate cancer
- Rôle de la voie sphingosine kinase/sphingosine 1-phosphate dans le contrôle de la division cellulaire
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