An ENU-induced point mutation in the mouse Btaf1 gene causes post-gastrulation embryonic lethality and protein instability.
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Summary
In isolation of a mouse line carrying a Btaf1 allele containing an ENU-induced point mutation that causes a substitution mutation in the BTAF1 ATPase domain, analyses in vitro suggest that the altered protein is less stable and, independent from this, functionally impaired in releasing of TBP from chromatin, but not in binding to TBP.
- Type
- article
- Published
- 2011-05-01
- Cited by
- 8
- References
- 29
- Access
- Open access
- OpenAlex
- https://openalex.org/W1969751957
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:235926
Keywords
Biology, Gastrulation, Lethality, Point mutation, Embryonic stem cell
References
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- Shifting Players and Paradigms in Cell-Specific Transcription
- Distinct promoter dynamics of the basal transcription factor TBP across the yeast genome
- Mot1, a global repressor of RNA polymerase II transcription, inhibits TBP binding to DNA by an ATP-dependent mechanism.
- The TATA box regulates TATA-binding protein (TBP) dynamics in vivo.
- The gene for human TATA-binding-protein-associated factor (TAFII) 170: structure, promoter and chromosomal localization.
- The dynamic personality of TATA-binding protein
- Mutational analysis of BTAF1–TBP interaction: BTAF1 can rescue DNA-binding defective TBP mutants
- TBP2 is essential for germ cell development by regulating transcription and chromatin condensation in the oocyte.
- Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
- The meaning of nonsense.
- A novel mutant allele of Ncx1: a single amino acid substitution leads to cardiac dysfunction.
- TBP dynamics in living human cells: constitutive association of TBP with mitotic chromosomes.
- Structure of the SWI2/SNF2 chromatin-remodeling domain of eukaryotic Rad54
- A phenotype-based screen for embryonic lethal mutations in the mouse.
- Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice.
Cited by
- Investigation of genetic and developmental defects in the L11Jus8 mutant mouse
- Mot1 Redistributes TBP from TATA-Containing to TATA-Less Promoters
- Time-dependent toxic effects of N-ethyl-N-nitrosourea on the testes of male C57BL/6J mice: a histological and ultrastructural study.
- Role of Cecr2 and Candidate Modifier Genes of Cecr2 in the Neural Tube Defect Exencephaly
- Mapping Genes Causing Syndromic and Non- Syndromic Human Hereditary Skin Disorders
- Potential SNPs and candidate genes influencing growth characteristics in Pakistani Beetal goat identified by GWAS analysis
- Genetic and clinical determinants of neonatal jaundice and growth patterns in the Qingdao birth cohort: A genome-wide association study
- Genome wide association study in goat identified novel SNPs and genes for growth
- Depletion of BTAF1 inhibits Epithelial-to-mesenchymal Transition via the TGF-β Signal pathway in the osteosarcoma
- Henikoff TATA-Containing to TATA-Less Promoters Mot 1 Redistributes TBP from
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