Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity
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Summary
DYn-2 is reported on, a new chemoselective probe for detecting sulfenylated proteins in human cells that reveals sulfenylation as a global signaling mechanism that is akin to phosphorylation and has regulatory implications for other receptor tyrosine kinases and irreversible inhibitors that target oxidant-sensitive cysteines in proteins.
- Type
- article
- Published
- 2011-12-11
- Cited by
- 459
- References
- 49
- Access
- Open access
- OpenAlex
- https://openalex.org/W1969360388
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2602275
Keywords
Epidermal growth factor receptor, Phosphorylation, Receptor tyrosine kinase, Kinase, Cell biology
References
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- Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo.
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- Redox Regulation of Protein Tyrosine Phosphatases: Structural and Chemical Aspects
Cited by
- Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?
- How the phagocyte NADPH oxidase regulates innate immunity
- Advances in Mechanisms of Anti-oxidation
- Probing the Role of Sulfenylation in Redox Regulation of Protein Kinases.
- ROS signaling and redox biology in endothelial cells
- Redox Regulation of EGFR Signaling Through Cysteine Oxidation
- A Caged Electrophilic Probe for Global Analysis of Cysteine Reactivity in Living Cells.
- Persulfidation (S-sulfhydration) and H2S.
- Protein-specific imaging of posttranslational modifications.
- Innate immune cell migration and function in response to damage associated signals
- Redox-regulation of PTPs; mechanisms and impact on PDGFR signaling
- Quantification of Protein Kinase Enzymatic Activity in Unfractionated Cell Lysates Using CSox-Based Sensors
- Global, in situ, site-specific analysis of protein S-sulphenylation
- Peroxide-dependent MGL sulfenylation regulates 2-AG-mediated endocannabinoid signaling in brain neurons
- Peroxiredoxins: Guardians Against Oxidative Stress and Modulators of Peroxide Signaling
- Methods to monitor classical protein-tyrosine phosphatase oxidation
- Hydrogen peroxide as a damage signal in tissue injury and inflammation: Murderer, mediator, or messenger?
- Mechanisms for redox-regulation of protein kinase C
- Profiling the reactivity of cyclic C-nucleophiles towards electrophilic sulfur in cysteine sulfenic acid
- Biological Chemistry and Functionality of Protein Sulfenic Acids and Related Thiol Modifications
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