Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture.
Explore this paper's citation graph
Summary
The differential expression of stress-sensitive TRPM2 and TRPV4 channels in hippocampal neurons and astrocytes that show distinct differences in vulnerability to different forms of oxidative stress suggests the specific involvement of these channels in oxidative stress-induced cell damage.
- Type
- article
- Published
- 2010-03-01
- Cited by
- 120
- References
- 70
- OpenAlex
- https://openalex.org/W1968470779
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33793900
Keywords
TRPM2, Oxidative stress, Cell biology, Chemistry, Flufenamic acid
References
- Ruthenium red-catalyzed degradation of peroxides can prevent mitochondrial oxidative damage induced by either tert-butyl hydroperoxide or inorganic phosphate.
- Regional vulnerability to endogenous and exogenous oxidative stress in organotypic hippocampal culture.
- Oxidant, mitochondria and calcium: an overview.
- Inhibition of TRPM2 cation channels by N‐(p‐amylcinnamoyl)anthranilic acid
- The versatility and universality of calcium signalling
- Ca2+‐dependent induction of TRPM2 currents in hippocampal neurons
- Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl homocysteine sulfoximine), a selective inhibitor of gamma-glutamylcysteine synthetase.
- Calcium and cell death: the mitochondrial connection.
- A critical role of TRPM2 in neuronal cell death by hydrogen peroxide.
- Rapid clearance of tertiary butyl hydroperoxide by cultured astroglial cells via oxidation of glutathione
- Organotypic hippocampal slice cultures for studies of brain damage, neuroprotection and neurorepair.
- Selective targeting of an antioxidant to mitochondria.
- Involvement of glutathione peroxidase and catalase in the disposal of exogenous hydrogen peroxide by cultured astroglial cells.
- Internal Ca2+ stores involved in anoxic responses of rat hippocampal neurons.
- Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration?
- TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage.
- Flufenamic acid is a pH-dependent antagonist of TRPM2 channels.
- Amyloid β‐peptide(1–42) and hydrogen peroxide‐induced toxicity are mediated by TRPM2 in rat primary striatal cultures
- Quantitative imaging of glutathione in hippocampal neurons and glia in culture using monochlorobimane
- A Novel TRPM2 Isoform Inhibits Calcium Influx and Susceptibility to Cell Death*
Cited by
- Antisense transcription at the TRPM2 locus as a novel prognostic marker and therapeutic target in prostate cancer
- TRP Channels Coordinate Ion Signalling in Astroglia
- Nonselective cation channels and links to hippocampal ischemia, aging, and dementia.
- Synthetic modulators of TRP channel activity.
- The Role of Oxidative Stress on Neural TRPC3, TRPC5, TRPC6 Expression and/or Function and Relevance to Bipolar Disorder
- Dopaminergic control of astrocytic calcium dynamics in situ and its potential effect on local synaptic activity
- Brain transient receptor potential channels and stroke
- TRPM2 protects against tissue damage following oxidative stress and ischaemia–reperfusion
- TRPM2 Cation Channels, Oxidative Stress and Neurological Diseases: Where Are We Now?
- Exploiting endobiotic metabolic pathways to target xenobiotic antioxidants to mitochondria.
- A Splice Variant of the Human Ion Channel TRPM2 Modulates Neuroblastoma Tumor Growth through Hypoxia-inducible Factor (HIF)-1/2α*
- Importance of TRP channels in pain: implications for stress.
- TRPM2 channel properties, functions and therapeutic potentials
- TRPM2 channel protective properties of N-acetylcysteine on cytosolic glutathione depletion dependent oxidative stress and Ca2+ influx in rat dorsal root ganglion.
- Role of TRPM2 in cell proliferation and susceptibility to oxidative stress.
- Melatonin modulates wireless (2.45 GHz)-induced oxidative injury through TRPM2 and voltage gated Ca(2+) channels in brain and dorsal root ganglion in rat.
- Involvement of TRPV4 channels in Aβ(40)-induced hippocampal cell death and astrocytic Ca(2+) signalling.
- The Increased Activity of TRPV4 Channel in the Astrocytes of the Adult Rat Hippocampus after Cerebral Hypoxia/Ischemia
- Activation of Transient Receptor Potential Vanilloid 4 Increases NMDA-Activated Current in Hippocampal Pyramidal Neurons
- Axonal Neuropathy-associated TRPV4 Regulates Neurotrophic Factor-derived Axonal Growth*
Related papers
- Transient Receptor Potential Melastatin 2:an Ion Channel for Oxidative Stress Sensing.
- Two Decades of Evolution of Our Understanding of the Transient Receptor Potential Melastatin 2 (TRPM2) Cation Channel
- In with the TRP Channels: Intracellular Functions for TRPM1 and TRPM2
- Transient receptor potential melastatin 2 channels in neurological disorders: Mechanisms and animal models
- Expression and regulation of transient receptor potential cation channel, subfamily M, member 2 (TRPM2) in human endometrium.
- TRPM2: a multifunctional ion channel for oxidative stress sensing.
- TRPM2 in the Brain: Role in Health and Disease
- TRPM2: a multifunctional ion channel for calcium signalling
- The transient receptor potential melastatin-2 (TRPM2) channel and inflammation