Visualizing the higher order folding of a catalytic RNA molecule.
Explore this paper's citation graph
Summary
Results directly demonstrate that divalent metal ions participate in general folding of the ribozyme tertiary structure, and further indicate a more specific involvement of Mg(II) in catalysis.
- Type
- article
- Published
- 1991-01-25
- Cited by
- 327
- References
- 53
- OpenAlex
- https://openalex.org/W1968455698
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25143293
Keywords
Ribozyme, RNA, Chemistry, Folding (DSP implementation), Tetrahymena
References
- Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena.
- Making ends meet: a model for RNA splicing in fungal mitochondria
- Hydroxyl radical footprinting: a high-resolution method for mapping protein-DNA contacts.
- Ribonuclease P: an enzyme with a catalytic RNA subunit.
- Identification of a cytidine-specific ribonuclease from chicken liver.
- Ribonuclease P: function and variation.
- RNA-catalysed synthesis of complementary-strand RNA
- Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena.
- Splice-site selection by a self-splicing RNA of Tetrahymena
- Mapping adenines, guanines, and pyrimidines in RNA.
- Hydroxyl radical "footprinting": high-resolution information about DNA-protein contacts and application to lambda repressor and Cro protein.
- Cation requirements of isoleucyl-tRNA synthetase from Escherichia coli.
- Simple RNA enzymes with new and highly specific endoribonuclease activities
- The guanosine binding site of the Tetrahymena ribozyme
- Structural conventions for group I introns.
- Catalytic activity is retained in the Tetrahymena group I intron despite removal of the large extension of element P5.
- Metal ion requirements for sequence-specific endoribonuclease activity of the Tetrahymena ribozyme.
- Self-cleavage of RNA in the replication of small pathogens of plants and animals.
- Laser temperature-jump, spectroscopic, and thermodynamic study of salt effects on duplex formation by dGCATGC.
- Folding and association of proteins.
Cited by
- An RNA fragment consisting of the P7 and P9.0 stems and the 3'-terminal guanosine of the Tetrahymena group I intron.
- A magnesium ion core at the heart of a ribozyme domain
- Emerging themes in RNA folding.
- Identification of the Minimal Essential RNA Sequences Responsible for Site-Specific Targeting of theLeishmania RNA Virus 1-4 Capsid Endoribonuclease
- A thermodynamic framework for the magnesium-dependent folding of RNA.
- New approaches to targeting RNA with oligonucleotides: inhibition of group I intron self-splicing.
- Inhibition of the group I ribozyme splicing by NADP+
- Relative orientation of RNA helices in a group 1 ribozyme determined by helix extension electron microscopy.
- Regulation of CAT protein by ribozyme and antisense mRNA in transgenic mice
- Antisense catalytic RNAs as therapeutic agents.
- Computational bioinformatics on three-dimensional structures of ribosomes using multiresolutional analysis
- Anatomy of Gene Regulation: A Three-Dimensional Structural Analysis
- Interpretation of Chemical Environments by RNA and the Implications to the Origins of Life
- Group I Introns and Homing Endonucleases in T-even-like Bacteriophages
- Structural changes of tRNA and 5S rRNA induced with magnesium and visualized with synchrotron mediated hydroxyl radical cleavage
- Twintrons: Introns-within-introns in the chloroplast genes of Euglena gracilis.
- Chemical nucleases: their use in studying RNA structure and RNA‐protein interactions
- Small angle X-ray scattering reveals a compact intermediate in RNA folding
- Probing RNA structure and function, by circular permutation.
- Application of circular dichroism to study RNA folding transitions.
Related papers
- A new type of hairpin ribozyme consisting of three domains.
- Construction of hairpin ribozymes with a three-way junction.
- Modification of primary structures of hairpin ribozymes for probing active conformations.
- Kinetic Mechanism of the Hairpin Ribozyme
- The many faces of the hairpin ribozyme: Structural and functional variants of a small catalytic rna
- The P9.1-P9.2 peripheral extension helps guide folding of the Tetrahymena ribozyme.
- Kinetic pathway for folding of the Tetrahymena ribozyme revealed by three UV-inducible crosslinks.
- Snapshots of the first-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM
- Folding mechanisms of group I ribozymes: role of stability and contact order.
- Computed Energetics of Nucleotides in Spatial Ribozyme Structures: An Accurate Identification of Functional Regions from Structure