Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis.
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Summary
Methylation of cytidine nucleotides in GSTP1 regulatory sequences constitutes the most common genomic alteration yet described for human prostate cancer.
- Type
- article
- Published
- 1994-11-22
- Cited by
- 892
- References
- 0
- Access
- Open access
- OpenAlex
- https://openalex.org/W1968391853
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21081091
Keywords
GSTP1, Biology, Carcinogenesis, DNA methylation, Methylation
References
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Cited by
- Promoter methylation status of tumor suppressor and tumor-related genes in neoplastic and non-neoplastic gastric epithelia.
- The concept of evolution in the pathogenesis and treatment of prostate cancer
- Methylation-mediated regulation of the glutathione S-transferase P1 gene in human breast cancer cells.
- Quantitative GSTP1 methylation clearly distinguishes benign prostatic tissue and limited prostate adenocarcinoma.
- Modest induction of phase 2 enzyme activity in the F-344 rat prostate
- Angiotensin II Induces Oxidative Stress in Prostate Cancer
- Glutathione S-Transferase P1 (GSTP1) gene polymorphism increases age-related susceptibility to hepatocellular carcinoma
- Epigenetic Deregulation Across Chromosome 2q14.2 Differentiates Normal from Prostate Cancer and Provides a Regional Panel of Novel DNA Methylation Cancer Biomarkers
- Epigenetic markers of ovarian cancer.
- The SNP rs6441224 influences transcriptional activity and prognostically relevant hypermethylation of RARRES1 in prostate cancer
- A positive feedback loop between ESE1/ELF3 and NF-κB promotes prostate cancer progression
- Cancer epigenetics.
- Mechanisms of prostate cancer initiation and progression.
- Hypermethylation of selected genes in endometrial carcinogenesis.
- Epigenetic Mechanisms for Progression of Prostate Cancer
- The use of transgenic animals to assess the role of metabolism in target organ toxicity.
- The epigenetic regulation of the EGF-receptor ligands Amphiregulin and Epiregulin and its impact on the outcome of EGFR-targeted therapies
- GSTA1 expression in normal, preneoplastic, and neoplastic human prostate tissue
- The role of microorganisms in prostate cancer development
- Prostate Cancer Epigenetics: A Review on Gene Regulation
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