Tumor progression despite massive influx of activated CD8+ T cells in a patient with malignant melanoma ascites
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Summary
Study of tumor-associated lymphocytes from a patient with metastatic melanoma and large volume malignant ascites suggests that, despite recruitment of large numbers of activated CD8+ T cells into the tumor microenvironment, T cell hyporesponsiveness and additional negative regulatory mechanisms can limit the effector phase of the anti-tumor immune response.
- Type
- article
- Published
- 2006-02-09
- Cited by
- 153
- References
- 28
- Access
- Open access
- OpenAlex
- https://openalex.org/W1968021577
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26447317
Keywords
Ascites, Melanoma, Cancer research, Medicine, CD8
References
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- Diversity and Recognition Efficiency of T Cell Responses to Cancer
- Immunoselection in vivo: Independent loss of MHC class I and melanocyte differentiation antigen expression in metastatic melanoma
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- PD-L1/B7H-1 Inhibits the Effector Phase of Tumor Rejection by T Cell Receptor (TCR) Transgenic CD8+ T Cells
Cited by
- Innate immune sensing of cancer: clues from an identified role for type I IFNs
- Inflammatory immune infiltration in human tumors: Role in pathogenesis and prognostic and diagnostic value
- Dendritic-Cell (DC)-Based Immunotherapy: Tumor Endothelial Marker 8 (TEM8) Gene Expression of DC Vaccines Correlates with Clinical Outcome
- Beta-2-microglobulin gene transfer in hla class i deficient tumor cells using recombinant adenovirus
- Immunological parameters as a new lead in the diagnosis of ovarian cancer
- The human T cell response to melanoma antigens.
- Persistence of Tumor-infiltrating CD8 T Cells is Tumor-dependent but Antigen-independent
- Distinct Role for CD8 T Cells toward Cutaneous Tumors and Visceral Metastases1
- Melanoma e inmunidad
- The next hurdle in cancer immunotherapy: Overcoming the non-T cell-inflamed tumor microenvironment
- PD‐1 expression on Melan‐A‐reactive T cells increases during progression to metastatic disease
- Tumor Response to Combination Celecoxib and Erlotinib Therapy in Non-small Cell Lung Cancer Is Associated with a Low Baseline Matrix Metalloproteinase-9 and a Decline in Serum-Soluble E-Cadherin
- Phase- and stage-related proportions of T cells bearing the transcription factor FOXP3 infiltrate primary melanoma.
- CD4+CD25+ regulatory T cells: a therapeutic target for liver diseases
- Dendritic cell based antitumor vaccination: impact of functional indoleamine 2,3-dioxygenase expression
- Early development of PAT-SM6 for the treatment of melanoma
- Selective accumulation of differentiated FOXP3+ CD4+ T cells in metastatic tumor lesions from melanoma patients compared to peripheral blood
- Rapid Maturation of Effector T Cells in Tumors, but Not Lymphoid Organs, during Tumor Regression
- Molecular profiling of melanoma and the evolution of patient-specific therapy
- Antigen-specific versus Antigen-nonspecific Immunotherapeutic Approaches for Human Melanoma: The Need for Integration for Optimal Efficacy?
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