Advances in Human Biology: Combining Genetics and Molecular Biophysics to Pave the Way for Personalized Diagnostics and Medicine
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Summary
The shift in focus in medicine towards more genomic-oriented practices is the foundation of personalized medicine and the progress made in these rapidly developing fields is outlined.
- Type
- article
- Published
- 2014-07-07
- Cited by
- 13
- References
- 224
- Access
- Open access
- OpenAlex
- https://openalex.org/W1967824040
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:83585099
Keywords
Pharmacogenomics, Personalized medicine, Genomics, Computational biology, Human genome
References
- Evaluation of Methods for De Novo Genome Assembly from High-Throughput Sequencing Reads Reveals Dependencies That Affect the Quality of the Results
- Structural Analysis of SHARPIN, a Subunit of a Large Multi-protein E3 Ubiquitin Ligase, Reveals a Novel Dimerization Function for the Pleckstrin Homology Superfold
- In silico study on the inhibitory interaction of drugs with wild-type CYP2D6.1 and the natural variant CYP2D6.17.
- Methods for identifying and studying genetic alterations in hormone-dependent cancers.
- Evaluation of the sequence template method for protein structure prediction. Discrimination of the (beta/alpha)8-barrel fold.
- Race as a proxy for drug response: the dangers and challenges of ethnic drugs.
- Predicting protein-DNA interactions by full search computational docking
- Creating a structural genomics consortium
- Enhancing Human Spermine Synthase Activity by Engineered Mutations
- Searching NCBI’s dbSNP database
- Discriminative topological features reveal biological network mechanisms
- CGMIM: Automated text-mining of Online Mendelian Inheritance in Man (OMIM) to identify genetically-associated cancers and candidate genes
- A novel p.Leu(381)Phe mutation in Presenilin 1 is associated with very early onset and unusually fast progressing dementia, and lysosomal inclusions typically seen in Kufs disease
- Research and applications: A rational free energy-based approach to understanding and targeting disease-causing missense mutations
- Beryllium disease among construction trade workers at Department of Energy nuclear sites.
- Predicting free energy changes using structural ensembles
- Protein–protein docking using 3D‐Dock in rounds 3, 4, and 5 of CAPRI
- Raising money for cystic fibrosis: At what price?
- The 1000 Genomes Project: Data Management and Community Access
- A qualitative study of lung cancer risk perceptions and smoking beliefs among national lung screening trial participants.
Cited by
- Investigating the linkage between disease-causing amino acid variants and their effect on protein stability and binding
- Personalized Biochemistry and Biophysics
- Structural and Physico-Chemical Effects of Disease and Non-Disease nsSNPs on Proteins
- Induced structural disorder as a molecular mechanism for enzyme dysfunction in phosphoglucomutase 1 deficiency
- Molecular Dynamics: New Frontier in Personalized Medicine.
- Genetic Epidemiology of Glucose-6-Phosphate Dehydrogenase Deficiency in the Arab World
- Structural Perspective on Revealing and Altering Molecular Functions of Genetic Variants Linked with Diseases
- Precision medicine review: rare driver mutations and their biophysical classification
- Modelling the Effects of Disease-Associated Single Amino Acid Variants and Rescuing the Effects by Small Molecules
- Autoinhibition can identify rare driver mutations and advise pharmacology
- Structural Perspective on Revealing and Altering Molecular Mechanisms of Genetic Variants Linked with Diseases
- Pan-cancer clinical impact of latent drivers from double mutations
- Review on Human Reference and Personal Genome Big Data Analysis
- Genetic Epidemiology of Glucose-6-Dehydrogenase Deficiency in the Arab World
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