SYD-1C, UNC-40 (DCC) and SAX-3 (Robo) Function Interdependently to Promote Axon Guidance by Regulating the MIG-2 GTPase
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Summary
It is shown that UNC-40, SAX-3 and the SYD-1 RhoGAP-like protein function interdependently to regulate the MIG-2 (Rac) GTPase in the HSN axon of C. elegans.
- Type
- article
- Published
- 2015-04-01
- Cited by
- 24
- References
- 59
- Access
- Open access
- OpenAlex
- https://openalex.org/W1966857451
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18616653
Keywords
Axon guidance, Biology, Netrin, Effector, Axon
References
- SYD-2 Liprin-α organizes presynaptic active zone formation through ELKS
- Netrin (UNC-6) mediates dendritic self-avoidance
- ENU‐3 functions in an UNC‐6/netrin dependent pathway parallel to UNC‐40/DCC/frazzled for outgrowth and guidance of the touch receptor neurons in C. elegans
- Support for shared ancestry of GAPs
- Relationship among guanine nucleotide exchange, GTP hydrolysis, and transforming potential of mutated ras proteins
- Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons.
- Hierarchical Organization of Guidance Receptors: Silencing of Netrin Attraction by Slit Through a Robo/DCC Receptor Complex
- Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance.
- A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila
- The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans.
- Slit stimulation recruits Dock and Pak to the roundabout receptor and increases Rac activity to regulate axon repulsion at the CNS midline.
- Loss of syd-1 from R7 neurons disrupts two distinct phases of presynaptic development
- Presenilin-dependent Receptor Processing is Required for Axon Guidance
- An UNC-40 pathway directs postsynaptic membrane extension in Caenorhabditis elegans
- Multiple Intrinsically Disordered Sequences Alter DNA Binding by the Homeodomain of the Drosophila Hox Protein Ultrabithorax*
- Integration of guidance cues: parallel signaling and crosstalk.
- Deleted in Colorectal Cancer (DCC) encodes a netrin receptor.
- The multifaceted roles of Slits and Robos in cortical circuits: from proliferation to axon guidance and neurological diseases.
- C. elegans ZAG-1, a Zn-finger-homeodomain protein, regulates axonal development and neuronal differentiation
- Role of a new Rho family member in cell migration and axon guidance in C. elegans.
Cited by
- Ulk1 Governs Nerve Growth Factor/TrkA Signaling by Mediating Rab5 GTPase Activation in Porcine Hemagglutinating Encephalomyelitis Virus-Induced Neurodegenerative Disorders
- SYD-1 promotes multiple developmental steps leading to neuronal connectivity
- Transition between synaptic branch formation and synaptogenesis is regulated by the lin-4 microRNA
- Cooperation and crosstalk in axon guidance cue integration: Additivity, synergy, and fine‐tuning in combinatorial signaling
- The Genetics of Axon Guidance and Axon Regeneration in Caenorhabditis elegans
- Rho GTPase‐activating proteins: Regulators of Rho GTPase activity in neuronal development and CNS diseases
- A Statistically-Oriented Asymmetric Localization (SOAL) Model for Neuronal Outgrowth Patterning by Caenorhabditis elegans UNC-5 (UNC5) and UNC-40 (DCC) Netrin Receptors
- Drosophila Syd-1 Has RhoGAP Activity That Is Required for Presynaptic Clustering of Bruchpilot/ELKS but Not Neurexin-1
- ZAG-1, a Zn-finger homeodomain transcription factor, affects neuronal outgrowth patterning by regulating UNC-40(DCC)-mediated outgrowth activity
- Robo and Ror function in a common receptor complex to regulate Wnt-mediated neurite outgrowth in Caenorhabditis elegans
- Distinct CED-10/Rac1 Domains Confer Context-Specific Functions in Neuronal Development
- Axon guidance pathway genes are associated with schizophrenia risk
- Distinct CED-10/Rac1 domains confer context-specific functions in development
- Serial synapse formation through filopodial competition for synaptic seeding factors
- Function of SYDE C2-RhoGAP family as signaling hubs for neuronal development deduced by computational analysis
- Small GTPases.
- The regulatory landscape of neurite development in Caenorhabditis elegans
- The ANC-1 (Nesprin-1/2) organelle-anchoring protein functions through mitochondria to polarize axon growth in response to SLT-1
- A short isoform of the UNC-6/Netrin receptor UNC-5 is required for growth cone polarity and robust growth cone protrusion in Caenorhabditis elegans
- Autism candidate gene rbm-26 (RBM26/27) regulates MALS-1 to protect against mitochondrial dysfunction and axon degeneration during neurodevelopment
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