Functional conservation of the lipid II biosynthesis pathway in the cell wall‐less bacteria Chlamydia and Wolbachia: why is lipid II needed?
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Summary
The hypothesis that the necessity for maintaining lipid II biosynthesis in cell wall‐lacking bacteria reflects an essential role of the precursor in prokaryotic cell division is discussed and the lipid II pathway may be exploited as an antibacterial target for chlamydial and filarial infections.
- Type
- article
- Published
- 2009-09-01
- Cited by
- 87
- References
- 40
- Access
- Open access
- OpenAlex
- https://openalex.org/W1966165352
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25554632
Keywords
Biology, Biosynthesis, Lipid II, Cell division, Biochemistry
References
- Survival of Wolbachia pipientis in Cell-Free Medium
- The Wolbachia Genome of Brugia malayi: Endosymbiont Evolution within a Human Pathogenic Nematode
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- Chlamydial classification, development and structure.
- Interaction of chlamydiae and host cells in vitro.
- Wolbachia Endosymbiotic Bacteria of Brugia malayi Mediate Macrophage Tolerance to TLR- and CD40-Specific Stimuli in a MyD88/TLR2-Dependent Manner1
- Effects of tetracycline on the filarial worms Brugia pahangi and Dirofilaria immitis and their bacterial endosymbionts Wolbachia.
- Functional and Biochemical Analysis of Chlamydia trachomatis MurC, an Enzyme Displaying UDP-N-Acetylmuramate:Amino Acid Ligase Activity
- Building the invisible wall: updating the chlamydial peptidoglycan anomaly.
- Antibiotics, peptidoglycan synthesis and genomics: the chlamydial anomaly revisited.
- Nisin-induced changes in Bacillus morphology suggest a paradigm of antibiotic action
- 299S1 DGHM Abstracts
- Genes for the peptidoglycan synthesis pathway are essential for chloroplast division in moss.
- Characterization of the lipid-carrier involved in the synthesis of enterobacterial common antigen (ECA) and identification of a novel phosphoglyceride in a mutant of Salmonella typhimurium defective in ECA synthesis.
- Phylogenomics of the Reproductive Parasite Wolbachia pipientis wMel: A Streamlined Genome Overrun by Mobile Genetic Elements
- Endosymbiotic bacteria in worms as targets for a novel chemotherapy in filariasis.
- Role of the amino acid invariants in the active site of MurG as evaluated by site-directed mutagenesis.
- l,l-diaminopimelate aminotransferase, a trans-kingdom enzyme shared by Chlamydia and plants for synthesis of diaminopimelate/lysine
- An Alternative Bactericidal Mechanism of Action for Lantibiotic Peptides That Target Lipid II
Cited by
- 2007 Astellas USA Foundation Award: Host-Guest Chemistry of the Peptidoglycan
- Rolle der NOD-Rezeptoren für die intrazelluläre Immunerkennung von Chlamydophila pneumoniae und Charakterisierung der chlamydialen NOD-Liganden
- Molecular mechanisms for the evolution of bacterial morphologies and growth modes
- Filarial and Wolbachia genomics
- Wolbachia filarial interactions
- The localization of key Bacillus subtilis penicillin binding proteins during cell growth is determined by substrate availability.
- Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membrane
- The AlternativeTranslational Profile That Underlies the Immune-Evasive State of Persistence in Chlamydiaceae Exploits Differential Tryptophan Contents of the Protein Repertoire
- AmiA is a penicillin target enzyme with dual activity in the intracellular pathogen Chlamydia pneumoniae
- The Chlamydial Anomaly Clarified?
- An oldie but a goodie - cell wall biosynthesis as antibiotic target pathway.
- Corallopyronin A - a promising antibiotic for treatment of filariasis.
- Comparative Genomics of Wolbachia and the Bacterial Species Concept
- Discovery of chlamydial peptidoglycan reveals bacteria with murein sacculi but without FtsZ
- Synthesis and biological evaluation of potential new inhibitors of the bacterial transferase MraY with a β-ketophosphonate structure.
- Functional Analysis of the Cytoskeleton Protein MreB from Chlamydophila pneumoniae
- FtsZ-independent septal recruitment and function of cell wall remodelling enzymes in chlamydial pathogens
- Cloning, Expression and Characterization of UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA) from Wolbachia Endosymbiont of Human Lymphatic Filarial Parasite Brugia malayi
- Requirement of lipid II biosynthesis for cell division in cell wall-less Wolbachia, endobacteria of arthropods and filarial nematodes.
- wALADin benzimidazoles differentially modulate the function of porphobilinogen synthase orthologs
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