Different species of alpha-synuclein oligomers induce calcium influx and seeding.

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Summary

The data indicate that inhibition of earlyalpha-syn aggregation events would consequently prevent all alpha-syn oligomer related toxicities, which has important implications for the development of disease-modifying drugs for the treatment of PD and other synucleinopathies.

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article
Published
2007-08-22
Cited by
389
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Keywords

Oligomer, Synucleinopathies, Alpha-synuclein, Fibril, Chemistry

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