Different species of alpha-synuclein oligomers induce calcium influx and seeding.
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Summary
The data indicate that inhibition of earlyalpha-syn aggregation events would consequently prevent all alpha-syn oligomer related toxicities, which has important implications for the development of disease-modifying drugs for the treatment of PD and other synucleinopathies.
- Type
- article
- Published
- 2007-08-22
- Cited by
- 389
- References
- 0
- Access
- Open access
- OpenAlex
- https://openalex.org/W1965888147
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26068416
Keywords
Oligomer, Synucleinopathies, Alpha-synuclein, Fibril, Chemistry
References
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- Loss of Functional Alpha-Synuclein: A Toxic Event in Parkinson’s Disease?
- Limelight on Alpha-Synuclein: Pathological and Mechanistic Implications in Neurodegeneration
- Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation
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