Vardenafil Enhances Oxytocin Expression in the Paraventricular Nucleus without Sexual Stimulation
Explore this paper's citation graph
Summary
It is shown that the PDE-5 inhibitor, vardenafil directly enhances oxytocin expression and also activates oxytoc in neurons in the paraventricular nucleus of conscious rats, which indicates that vardenAFil may exert positive effects on affiliation behavior and social interaction.
- Type
- article
- Published
- 2010-12-01
- Cited by
- 5
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W1965228205
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18157273
Keywords
Vardenafil, Oxytocin, Medicine, Stimulation, Nucleus
References
- Effect of vardenafil on cerebral vasospasm following experimental subarachnoid hemorrhage in rats.
- Augmentation of the NO-cGMP cascade induces anxiogenic-like effect in mice.
- Involvement of the brain oxytocin system in stress coping: interactions with the hypothalamo-pituitary-adrenal axis.
- Early experience in humans is associated with changes in neuropeptides critical for regulating social behavior.
- OXYTOCIN MAY MEDIATE THE BENEFITS OF POSITIVE SOCIAL INTERACTION AND EMOTIONS 1 The purpose of this
- The use of c-fos as a metabolic marker in neuronal pathway tracing.
- Intracerebroventricular oxytocin stimulates maternal behaviour in the sheep.
- Psychosocial side effects of sildenafil therapy for erectile dysfunction.
- Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication.
- Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala
- Effects of excitatory amino acids and nitric oxide on flight behavior elicited from the dorsolateral periaqueductal gray.
- Naloxone potentiates treadmill running-induced increase in c-Fos expression in rat hippocampus.
- Oxytocin--a neuropeptide for affiliation: evidence from behavioral, receptor autoradiographic, and comparative studies.
- Effects of the PDE5-inhibitor vardenafil in a mouse stroke model.
- Social Interaction Deficits Caused by Chronic Phencyclidine Administration are Reversed by Oxytocin
- Vardenafil prevents fibrosis and loss of corporal smooth muscle that occurs after bilateral cavernosal nerve resection in the rat.
- Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress.
- Enhanced social interactions in rats following chronic, centrally infused oxytocin.
- Vardenafil: A new approach to the treatment of erectile dysfunction
- Stimulus-transcription coupling in neurons: role of cellular immediate-early genes.
Cited by
- Cyclic nucleotide signaling and synaptic plasticity
- Repeated and chronic administration of Vardenafil or Sildenafil differentially affects emotional and socio-sexual behavior in mice.
- Oxytocin: a therapeutic target for mental disorders
- Antidepressant-like effect of sildenafil through oxytocin-dependent cyclic AMP response element-binding protein phosphorylation.
- Beyond Erectile Dysfunction: Understanding PDE5 Activity In The Central Nervous System
Related papers
- Vardenafil in Erectile Dysfunction: The Evidence of Its Therapeutic Value
- Efficacy and tolerability of vardenafil in men with mild depression and erectile dysfunction: the depression-related improvement with vardenafil for erectile response study.
- Vardenafil in treatment of erectile dysfunction: a report of 178 cases
- Safety and efficacy of vardenafil, a selective phosphodiesterase 5 inhibitor, in patients with erectile dysfunction and arterial hypertension treated with multiple antihypertensives.
- Visual loss with erectile dysfunction medications
- Vardenafil- A new and effective treatment for erectile dysfunction