Effect of Mechanical Loading on Three-Dimensional Cultures of Embryonic Stem Cell-Derived Cardiomyocytes
Explore this paper's citation graph
Summary
This study describes a 3-dimensional model to examine the direct effect of mechanical loading on the differentiation of ESC-derived cardiomyocytes embedded in a defined extracellular matrix scaffold and found that cues from their environment can drive phenotypic control andCardiomyocyte differentiation.
- Type
- article
- Published
- 2008-01-01
- Cited by
- 124
- References
- 58
- Access
- Open access
- OpenAlex
- https://openalex.org/W1965184563
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20532653
Keywords
Embryonic stem cell, Extracellular matrix, Cell biology, Gene expression, Myosin
References
- Induction of atrial natriuretic factor and myosin light chain-2 gene expression in cultured ventricular myocytes by electrical stimulation of contraction.
- Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy.
- Chronic stretch of engineered heart tissue induces hypertrophy and functional improvement
- Embryonic stem cells cultured in biodegradable scaffold repair infarcted myocardium in mice.
- Mechanical stretch activates the stress‐activated protein kinase in cardiac myocytes
- Cooperative Interaction between GATA-4 and GATA-6 Regulates Myocardial Gene Expression
- Pulsatile Myocardial Tubes Fabricated With Cell Sheet Engineering
- The Transcription Factors GATA4 and GATA6 Regulate Cardiomyocyte Hypertrophy in Vitro and in Vivo *
- Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C.
- Genetically selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac grafts.
- Construction of a bioengineered cardiac graft.
- Design and Application of a Test System for Viscoelastic Characterization of Collagen Gels
- Biomechanics: Mechanical Properties of Living Tissues
- Polyurethane films seeded with embryonic stem cell-derived cardiomyocytes for use in cardiac tissue engineering applications.
- Optimizing Engineered Heart Tissue for Therapeutic Applications as Surrogate Heart Muscle
- Tissue Engineering of a Differentiated Cardiac Muscle Construct
- GATA4 is a dosage-sensitive regulator of cardiac morphogenesis.
- Controlling the Cellular Organization of Tissue‐Engineered Cardiac Constructs
- Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
- Generation of confluent cardiomyocyte monolayers derived from embryonic stem cells in suspension: a cell source for new therapies and screening strategies.
Cited by
- Cell culture platform with mechanical conditioning and nondamaging cellular detachment.
- Modelling of some biological materials using continuum mechanics
- Electrical and mechanical stimulation of cardiac cells and tissue constructs
- The bioartificial pancreas (BAP): Biological, chemical and engineering challenges.
- Differentiation of Embryonic Stem Cells into Cardiomyocytes in a Microfluidic System
- Development of micro electro mechanical devices for the study of mechanosensitive ion channels and mechanical cell properties
- Effect of Substrate Mechanics on Cardiomyocyte Maturation and Growth
- Role of Mechanical Strain on the Cardiomyogenic Differentiation of Periodontal Ligament Derived Stem Cells
- Concise Review: Growing Hearts in the Right Place: On the Design of Biomimetic Materials for Cardiac Stem Cell Differentiation
- Bioreactors for guiding muscle tissue growth and development.
- Controlled electromechanical cell stimulation on-a-chip
- Assessment of Cytostretch - A Heart-On-Chip device. Experiments on Cardiomyocytes
- Cardiomyocyte culture - an update on the in vitro cardiovascular model and future challenges.
- Immaturity of Human Stem-Cell-Derived Cardiomyocytes in Culture: Fatal Flaw or Soluble Problem?
- Microsystems for biomimetic stimulation of cardiac cells.
- A Novel Miniaturized Multimodal Bioreactor for Continuous In Situ Assessment of Bioartificial Cardiac Tissue During Stimulation and Maturation
- Engineering three-dimensional cell mechanical microenvironment with hydrogels
- Combining Hypoxia and Bioreactor Hydrodynamics Boosts Induced Pluripotent Stem Cell Differentiation Towards Cardiomyocytes
- Mechanobiology of Cardiomyocyte Development
- Murine and human pluripotent stem cell-derived cardiac bodies form contractile myocardial tissue in vitro.
Related papers
- Mechanotransduction in intervertebral discs
- Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface
- The Driving Force: Nuclear Mechanotransduction in Cellular Function, Fate, and Disease
- Review of cellular mechanotransduction on micropost substrates
- Review of Cellular Mechanotransduction
- The Elusive Mechanotransduction Machinery of Hair Cells
- Physiological and pharmacological role of lysophosphatidic acid as modulator in mechanotransduction.
- Slow and fast myosin heavy chain content defines three types of myotubes in early muscle cell cultures