Decreased energy and phosphorylation status in the liver of lung cancer patients with weight loss.
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Summary
Hepatic ATP and phosphorylation status are reduced in WL lung cancer patients, in contrast to WS patients and healthy subjects, and continue to decrease during infusion of a gluconeogenic substrate, suggesting impaired energy regenerating capacity in these patients.
- Type
- article
- Published
- 2000-06-01
- Cited by
- 25
- References
- 28
- Access
- Open access
- OpenAlex
- https://openalex.org/W1965181266
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20514741
Keywords
Lung cancer, Internal medicine, Bioenergetics, Liver cancer, Medicine
References
- Biochemistry for the Medical Sciences
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- Altered glucose metabolism in metastatic carcinoma.
- O.35 Increased rates of gluconeogenesis from alanine in weight-losing lung cancer patients
- Non-T1-weighted 31P chemical shift imaging of the human liver.
- Effect of alanine concentration independent of changes in insulin and glucagon on alanine and glucose homeostasis in the conscious dog.
- Altered phosphorylation status, phospholipid metabolism and gluconeogenesis in the host liver of rats with prostate cancer: a 31P magnetic resonance spectroscopy study.
- Weight loss and Cachexia in lung cancer
- The metabolic state of the rat liver in vivo measured by 31P-NMR spectroscopy.
- The Effect of Tumor Bulk on the Metabolic Response to Cancer
- Effect of alanine infusion on glucose and urea production in man.
- Metabolic alterations in a noncachectic animal tumor system
- Understanding the discrepancies between 31P MR spectroscopy assessed liver metabolite concentrations from different institutions.
- Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group.
- In vivo assessment of metabolic perturbations following alanine and glucagon administration using 31P-MRS in the rat.
- Amiloride and amiloride analogs inhibit Na+/K+-transporting ATPase and Na+-coupled alanine transport in rat hepatocytes.
Cited by
- Dynamic contrast-enhanced CT in the investigation of tumour angiogenesis and haemodynamics
- Evidence for altered hepatic gluconeogenesis in patients with cirrhosis using in vivo 31-phosphorus magnetic resonance spectroscopy
- Parametric exploration of the liver by magnetic resonance methods
- Clinical Magnetic Resonance Spectroscopy
- Adenosine triphosphate infusion increases liver energy status in advanced lung cancer patients: An in vivo 31P magnetic resonance spectroscopy study
- AMP-activated Protein Kinase α2 Protects against Liver Injury from Metastasized Tumors via Reduced Glucose Deprivation-induced Oxidative Stress*
- Magnetic resonance spectroscopy to study hepatic metabolism in diffuse liver diseases, diabetes and cancer.
- Abnormal hepatic energy homeostasis in type 2 diabetes
- Measuring short-term liver metabolism non-invasively: postprandial and post-exercise 1H and 31P MR spectroscopy
- Ectopic lipids and organ function
- Beneficial effects of adenosine triphosphate on nutritional status in advanced lung cancer patients: a randomized clinical trial.
- Potential value of adenosine 5'-triphosphate (ATP) and adenosine in anaesthesia and intensive care medicine.
- Ethanol feeding enhances age-related deterioration of the rat hepatic mitochondrion.
- REVIEW ARTICLE Potential value of adenosine 5 0 -triphosphate (ATP) and adenosine in anaesthesia and intensive care medicine
- Plasma and tissue free amino acid profiles and their concentration correlation in patients with lung cancer.
- MALDI-TOF MS imaging of metabolites with a N-(1-naphthyl) ethylenediamine dihydrochloride matrix and its application to colorectal cancer liver metastasis.
- Variants in Genes Controlling Oxidative Metabolism Contribute to Lower Hepatic ATP Independent of Liver Fat Content in Type 1 Diabetes
- Adipose tissue and liver.
- Impaired Bioenergetics in Clinical Medicine: A Target to Tackle.
- Surgical approach of bronchogenic cancer in correlation with tumor type and risk factors
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