Roles for RNA in telomerase nucleotide and repeat addition processivity.
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Summary
Additional roles of the telomerase RNA subunit are established by demonstrating that RNA motifs stimulate the processivity of nucleotide and repeat addition, which are both functionally and physically separable from the roles of otherRNA motifs in establishing a properly defined template.
- Type
- article
- Published
- 2003-06-01
- Cited by
- 90
- References
- 52
- Access
- Open access
- OpenAlex
- https://openalex.org/W1965130367
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10365513
Keywords
Processivity, Biology, Ribonucleoprotein, RNA, Pseudoknot
References
- Telomerase recognizes its template by using an adjacent RNA motif
- Functional Analysis of the C-terminal Extension of Telomerase Reverse Transcriptase
- Joining of RNAs by splinted ligation.
- Architecture of telomerase RNA.
- The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku
- Protection of mammalian telomeres
- Non–coding RNA genes and the modern RNA world
- The end of the (DNA) line
- Telomerase is processive
- Analysis of telomerase processivity: mechanistic similarity to HIV-1 reverse transcriptase and role in telomere maintenance.
- Requirements for the dGTP-dependent Repeat Addition Processivity of Recombinant TetrahymenaTelomerase*
- Template boundary in a yeast telomerase specified by RNA structure.
- Effect of dGTP concentration on human and CHO telomerase.
- Specific telomerase RNA residues distant from the template are essential for telomerase function.
- Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro.
- Reverse transcriptase motifs in the catalytic subunit of telomerase.
- A conserved pseudoknot in telomerase RNA.
- Functional Analysis of Conserved Residues in the Putative “Finger” Domain of Telomerase Reverse Transcriptase*
- Template definition by Tetrahymena telomerase reverse transcriptase
- A functional telomerase RNA swap in vivo reveals the importance of nontemplate RNA domains.
Cited by
- Telomere and telomerase biology.
- Model for processive nucleotide and repeat additions by the telomerase
- Noncoding RNA Control of Cellular Senescence
- Structure of stem‐loop IV of Tetrahymena telomerase RNA
- La sets the tone for telomerase assembly
- A modified model for translocation events of processive nucleotide and repeat additions by the recombinant telomerase.
- Structural features of mouse telomerase RNA are responsible for the lower activity of mouse telomerase versus human telomerase.
- A novel motif in telomerase reverse transcriptase regulates telomere repeat addition rate and processivity
- Telomerase and its extracurricular activities
- The biogenesis and regulation of telomerase holoenzymes
- Telomerase: Structure, functions, and activity regulation
- A dynamic model for transcription elongation and sequence-dependent short pauses by RNA polymerase
- The unmasking of telomerase.
- Telomerase RNA: a flexible RNA scaffold for telomerase biosynthesis.
- Stepwise protein-mediated RNA folding directs assembly of telomerase ribonucleoprotein
- Telomerase structure paves the way for new cancer therapies.
- Mutation in TERT separates processivity from anchor-site function
- Structure–function relationship and biogenesis regulation of the human telomerase holoenzyme
- A telomerase holoenzyme protein enhances telomerase RNA assembly with telomerase reverse transcriptase
- Telomerase: Structure and properties of the enzyme, and peculiarities of yeast telomerase
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