The effect of concentration, thermal history and cell seeding density on the initial mechanical properties of agarose hydrogels.
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Summary
The equilibrium and dynamic compressive modulus of agarose hydrogels were observed to reduce if maintained at 37 ( composite function)C following gelation compared with samples maintained at room temperature, and depending on the methodology used to encapsulate chondrocytes within agaroses, the equilibrium compressiveModulus was found to be significantly higher than the compressive equilibrium modulus.
- Type
- article
- Published
- 2009-10-01
- Cited by
- 153
- References
- 58
- Access
- Open access
- OpenAlex
- https://openalex.org/W1965075111
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10532860
Keywords
Agarose, Self-healing hydrogels, Materials science, Ultimate tensile strength, Elastic modulus
References
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- Injectable hydrogels for cartilage tissue engineering
- Proteoglycan deposition around chondrocytes in agarose culture: Construction of a physical and biological interface for mechanotransduction in cartilage
- Upregulation of aggrecan and type II collagen mRNA expression in bovine chondrocytes by the application of hydrostatic pressure
- Dynamic deformational loading results in selective application of mechanical stimulation in a layered, tissue-engineered cartilage construct
- Functional tissue engineering of chondral and osteochondral constructs
- The influence of repair tissue maturation on the response to oscillatory compression in a cartilage defect repair model
- The influence of mechanical loading on isolated chondrocytes seeded in agarose constructs
- Influence of thermal history on the structural and mechanical properties of agarose gels.
- Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs.
- New insight into agarose gel mechanical properties.
- Tensile properties of human knee joint cartilage: I. Influence of ionic conditions, weight bearing, and fibrillation on the tensile modulus
- Effects of Cyclic Compressive Loading on Chondrogenesis of Rabbit Bone‐Marrow Derived Mesenchymal Stem Cells
- Expression of the human chondrocyte phenotype in vitro
- Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells.
- Transplantation of allograft chondrocytes embedded in agarose gel into cartilage defects of rabbits.
- New insight into deformation-dependent hydraulic permeability of gels and cartilage, and dynamic behavior of agarose gels in confined compression.
- Low-density cultures of bovine chondrocytes: effects of scaffold material and culture system.
- The influence of elaborated pericellular matrix on the deformation of isolated articular chondrocytes cultured in agarose.
- Variations in matrix composition and GAG fine structure among scaffolds for cartilage tissue engineering.
Cited by
- Cell microcarriers and microcapsules of stimuli-responsive polymers.
- Cell Seeding Densities in Autologous Chondrocyte Implantation Techniques for Cartilage Repair
- Tissue Engineered Cartilage in Unconfined Compression: Biomechanical Analysis☆
- Biomechanical aspects of the anterior segment in human myopia
- The influence of matrix elasticity on chondrocyte behavior in 3D
- Composite Chitosan/Agarose Ferrogels for Potential Applications in Magnetic Hyperthermia
- Novel 3D-Printed Device for the Simple Preparation of Hydrogel Beads
- The effects of fibrin and fibrin‐agarose on the extracellular matrix profile of bioengineered oral mucosa
- Strategies for engineering cartilage with improved content and organization
- Chondrogenic potential of physically treated bovine cartilage matrix derived porous scaffolds on human dermal fibroblast cells.
- Glycosaminoglycan Dependent Isolation of Mesenchymal Chondroprogenitor Populations from Human Bone Marrow
- The effect of cyclic hydrostatic pressure on the functional development of cartilaginous tissues engineered using bone marrow derived mesenchymal stem cells.
- High-concentration compact agar gels from hydrothermal synthesis
- Direct Noninvasive Measurement and Numerical Modeling of Depth-Dependent Strains in Layered Agarose Constructs
- Gradient‐Regulated Hydrogel for Interface Tissue Engineering: Steering Simultaneous Osteo/Chondrogenesis of Stem Cells on a Chip
- Role of Pericellular Matrix in Mesenchymal Stem Cell Deformation during Chondrogenic Differentiation
- Rheometric study of chitosan/activated carbon composite hydrogels for medical applications using an experimental design
- Alteration of bacterial adhesion induced by the substrate stiffness.
- Effects of Cell Density on Mechanical Properties of Alginate Hydrogel Tissue Scaffolds
- Integrating-sphere measurements for determining optical properties of tissue-engineered oral mucosa
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