Permissive role of protein kinase C alpha but not protein kinase C delta in sphingosine 1-phosphate-induced Rho A activation in C2C12 myoblasts.
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Summary
It is shown that in C2C12 myoblasts sphingosine 1-phosphate rapidly and transiently induced membrane association of Rho A in a pertussis toxin-insensitive manner, and the bioactive lipid preferentially relocalized the GTPase to Golgi-enriched membrane.
- Type
- article
- Published
- 2000-09-28
- Cited by
- 19
- References
- 0
- Access
- Open access
- OpenAlex
- https://openalex.org/W1965064988
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7757714
Keywords
C2C12, RHOA, Sphingosine-1-phosphate, Protein kinase A, Cell biology
References
Cited by
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- New signalling pathway involved in the anti-proliferative action of vitamin D₃ and its analogues in human neuroblastoma cells. A role for ceramide kinase.
- Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function.
- Vanadate activates Rho A translocation in association with contracting effects in ileal longitudinal smooth muscle of guinea pig.
- Sphingosine 1‐phosphate regulates myogenic differentiation: a major role for S1P2 receptor
- AKAP-Lbc nucleates a protein kinase D activation scaffold.
- Rho-Kinase Mediates Hyperglycemia-Induced Plasminogen Activator Inhibitor-1 Expression in Vascular Endothelial Cells
- Transforming Growth Factor-β1 Induces Transdifferentiation of Myoblasts into Myofibroblasts via Up-Regulation of Sphingosine Kinase-1/S1P3 Axis
- Regulation of transient receptor potential canonical channel 1 (TRPC1) by sphingosine 1-phosphate in C2C12 myoblasts and its relevance for a role of mechanotransduction in skeletal muscle differentiation
- Sphingosine 1-phosphate axis: a new leader actor in skeletal muscle biology
- Frontiers in Skeletal Muscle Wasting, Regeneration and Stem Cells
- S1P/S1P Receptor Signaling in Neuromuscolar Disorders
- REVIEWS Intracellular Signal for Skeletal Muscle Adaptation Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function
- Regulation of transient receptor potential canonical channel 1 (TRPC1) by sphingosine 1-phosphate in C2C12 myoblasts and its relevance for a role of mechanotransduction in skeletal muscle differentiation
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