Permissive role of protein kinase C alpha but not protein kinase C delta in sphingosine 1-phosphate-induced Rho A activation in C2C12 myoblasts.

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Summary

It is shown that in C2C12 myoblasts sphingosine 1-phosphate rapidly and transiently induced membrane association of Rho A in a pertussis toxin-insensitive manner, and the bioactive lipid preferentially relocalized the GTPase to Golgi-enriched membrane.

Type
article
Published
2000-09-28
Cited by
19
References
0
Access
Open access

Keywords

C2C12, RHOA, Sphingosine-1-phosphate, Protein kinase A, Cell biology

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