Generation of a Novel Regulatory NK Cell Subset from Peripheral Blood CD34+ Progenitors Promoted by Membrane-Bound IL-15

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Summary

In conclusion, NK-ireg cells represent a novel truly differentiated non-cytolytic NK subset with a self-sustainable phenotype generated from specific pSTAT6+ GATA3+ precursors and could be employed to develop new immuno-suppressive strategies in autoimmune diseases, transplant rejection or graft versus host diseases.

Type
article
Published
2008-05-21
Cited by
54
References
67
Access
Open access

Keywords

Cell biology, Interleukin 21, Biology, Interleukin 12, Janus kinase 3

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