Generation of a Novel Regulatory NK Cell Subset from Peripheral Blood CD34+ Progenitors Promoted by Membrane-Bound IL-15
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Summary
In conclusion, NK-ireg cells represent a novel truly differentiated non-cytolytic NK subset with a self-sustainable phenotype generated from specific pSTAT6+ GATA3+ precursors and could be employed to develop new immuno-suppressive strategies in autoimmune diseases, transplant rejection or graft versus host diseases.
- Type
- article
- Published
- 2008-05-21
- Cited by
- 54
- References
- 67
- Access
- Open access
- OpenAlex
- https://openalex.org/W1964990642
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17529179
Keywords
Cell biology, Interleukin 21, Biology, Interleukin 12, Janus kinase 3
References
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- Cutting Edge: Immature Human Dendritic Cells Express Latency-Associated Peptide and Inhibit T Cell Activation in a TGF-β-Dependent Manner1
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- Constitutive and IFN-gamma regulated expression of IL-7 and IL-15 in human renal cell cancer.
- Immuno-tolerogenic functions of HLA-G: relevance in transplantation and oncology.
- A brief review of recent data on some cytokine expressions at the materno-foetal interface which might challenge the classical Th1/Th2 dichotomy.
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- IL‐21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig‐like receptors
- Interferon gamma bound to extracellular matrix changes the hyporesponsiveness to LPS in crypt but not villous intestinal epithelial cells.
- IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation.
- Analysis of natural killer cells isolated from human decidua: Evidence that 2B4 (CD244) functions as an inhibitory receptor and blocks NK-cell function.
- Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2.
- Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46
Cited by
- Natural killer cell tolerance licensing and other mechanisms.
- Generation of Natural Killer Cells from Umbilical Cord Blood Stem Cells, Characterisation and Application for Immunotherapy
- Polymorphisme du gène NCR3/NKp30 et variabilité de la fonction des cellules Natural Killer humaines
- Peripheral blood NK cells expressing HLA-G, IL-10 and TGF-β in healthy donors and breast cancer patients.
- Decreased NK Cell Frequency and Function Is Associated with Increased Risk of KIR3DL Allele Polymorphism in Simian Immunodeficiency Virus-Infected Rhesus Macaques with High Viral Loads
- The β2 integrin CD11b attenuates polyinosinic:Polycytidylic acid–induced hepatitis by negatively regulating natural killer cell functions
- Role of NFKB2 on the early myeloid differentiation of CD34+ hematopoietic stem/progenitor cells.
- HLA-G expression is irrelevant to prognosis in patients with acute myeloid leukemia.
- Cytokine regulation of natural killer cell effector functions
- Effects of Natalizumab on Circulating B Cells, T Regulatory Cells and Natural Killer Cells
- CD8+ NK cells are predominant in chimpanzees, characterized by high NCR expression and cytokine production, and preserved in chronic HIV‐1 infection
- Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists.
- Natural killer cells in atopic and autoimmune diseases of the skin.
- Engineering of the immune system for human ESC- and iPSC-derived grafts
- HLA-G-dependent suppressor cells: Diverse by nature, function, and significance.
- Generation of natural killer cells from hematopoietic stem cells in vitro for immunotherapy
- CD16- natural killer cells: enrichment in mucosal and secondary lymphoid tissues and altered function during chronic SIV infection.
- Role of Common-Gamma Chain Cytokines in NK Cell Development and Function: Perspectives for Immunotherapy
- The natural killer cell: a further innate mediator of gouty inflammation?
- TLRs, macrophages, and NK cells: our understandings of their functions in uterus and ovary.
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