Challenges to macromolecular drug delivery.
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Summary
The challenges to contemporary macromolecule drug delivery are complex, thus new research paradigms are emerging that combine the talents of physical and biological scientists to address this key issue for modern pharmacology and therapeutics.
- Type
- review
- Published
- 2007-02-01
- Cited by
- 38
- References
- 25
- OpenAlex
- https://openalex.org/W1964868149
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18597934
Keywords
Drug delivery, Biodistribution, Computational biology, Drug, Drug discovery
References
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- Evolving endosomes: how many varieties and why?
- Evaluating the Specificity of Antisense Oligonucleotide Conjugates
- Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides.
- Nanotechnology for drug and gene therapy: the importance of understanding molecular mechanisms of delivery.
- Virus Entry: Open Sesame
- Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity.
Cited by
- Biodistribution Studies of Nanoparticles Using Fluorescence Imaging: A Qualitative or Quantitative Method?
- Exploring the synthetic possibilities and siRNA delivery potential of small molecule carriers (SMoCs)
- Nano-Enabled Delivery of Diverse Payloads Across Complex Biological Barriers
- siRNA Delivery: From Lipids to Cell‐penetrating Peptides and Their Mimics
- BIONANOTECNOLOGÍA Y NANOBIOTECNOLOGÍA: CÓMO APROVECHAR EL MICROCOSMOS
- Construction and expression of anti-CD62P/anti-GPIIb-IIIa diabody.
- Cellular uptake and cytotoxicity of silica nanotubes.
- Host-rotaxanes with oligomeric axles are intracellular transport agents.
- Recent advances in topical delivery of proteins and peptides mediated by soft matter nanocarriers.
- A Novel GAP460 Biopolymer for Use as a Carrier in Drug-Delivery Applications
- Longer action means better drug: tuning up protein therapeutics.
- Nanoplatforms for constructing new approaches to cancer treatment, imaging, and drug delivery: What should be the policy?
- Fluorescence imaging with multifunctional polyglycerol sulfates: novel polymeric near-IR probes targeting inflammation.
- Accurate targeting of activated macrophages based on synergistic activation of functional molecules uptake by scavenger receptor and matrix metalloproteinase.
- Alkyne-Azide “Click” Chemistry in Designing Nanocarriers for Applications in Biology
- Potential efficacy of cell-penetrating peptides for nucleic acid and drug delivery in cancer.
- The cellular uptake of meta-tetra(hydroxyphenyl)chlorin entrapped in organically modified silica nanoparticles is mediated by serum proteins
- EL ROL DE LAS UNIVERSIDADES EN LA SOCIEDAD DEL CONOCIMIENTO Y EN LA ERA DE LA GLOBALIZACIÓN: EVIDENCIA DESDE CHILE
- Immobilized thermolysin for highly efficient production of low-molecular-weight protamine--an attractive cell-penetrating peptide for macromolecular drug delivery applications.
- Nano Drug Delivery System in Pharmacy and Chemistry Review Article
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