Coronary Heart Disease-Associated Variation in TCF21 Disrupts a miR-224 Binding Site and miRNA-Mediated Regulation
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Summary
These studies implicating rs12190287 in the miRNA-dependent regulation of TCF21, in conjunction with previous studies showing that this variant modulates transcriptional regulation through activator protein 1 (AP-1), suggests a unique bimodal level of complexity previously unreported for disease-associated variants.
- Type
- article
- Published
- 2014-03-01
- Cited by
- 109
- References
- 56
- Access
- Open access
- OpenAlex
- https://openalex.org/W1964655626
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17161446
Keywords
Biology, Allele, microRNA, Untranslated region, Three prime untranslated region
References
- A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
- Cloning of capsulin, a basic helix-loop-helix factor expressed in progenitor cells of the pericardium and the coronary arteries.
- Capsulin: a novel bHLH transcription factor expressed in epicardial progenitors and mesenchyme of visceral organs.
- The Wilms' tumor gene product represses the transcription of thrombospondin 1 in response to overexpression of c-Jun
- Genetic variation in microRNA networks: the implications for cancer research
- A theoretical approach to select effective antisense oligodeoxyribonucleotides at high statistical probability.
- Disease-Related Growth Factor and Embryonic Signaling Pathways Modulate an Enhancer of TCF21 Expression at the 6q23.2 Coronary Heart Disease Locus
- Distinctive microRNA signature of medulloblastomas associated with the WNT signaling pathway.
- TCF21 and PCDH17 methylation: An innovative panel of biomarkers for a simultaneous detection of urological cancers
- Platelet-derived growth factor and its role in health and disease.
- Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease
- Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure.
- Allelic imbalance sequencing reveals that single-nucleotide polymorphisms frequently alter microRNA-directed repression
- Implications of RNA structure on the annealing of a potent antisense RNA directed against the human immunodeficiency virus type 1.
- Differential expression of embryonic epicardial progenitor markers and localization of cardiac fibrosis in adult ischemic injury and hypertensive heart disease
- Most mammalian mRNAs are conserved targets of microRNAs.
- Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium-derived cells into smooth muscle in the developing heart
- Complementary large loops determine the rate of RNA duplex formation in vitro in the case of an effective antisense RNA directed against the human immunodeficiency virus type 1.
- RNA Chaperones, RNA Annealers and RNA Helicases
- MicroRNAs in Vascular Biology and Vascular Disease
Cited by
- The short and long of noncoding sequences in the control of vascular cell phenotypes
- Path from schizophrenia genomics to biology: gene regulation and perturbation in neurons derived from induced pluripotent stem cells and genome editing
- Genetic Variations in MicroRNA-Binding Sites Affect MicroRNA-Mediated Regulation of Several Genes Associated With Cardio-metabolic Phenotypes
- Lipid-Induced Epigenomic Changes in Human Macrophages Identify a Coronary Artery Disease-Associated Variant that Regulates PPAP2B Expression through Altered C/EBP-Beta Binding
- MicroRNA Regulation of Vascular Smooth Muscle Function and Phenotype: Early Career Committee Contribution
- Identifying functional noncoding variants from genome-wide association studies for cardiovascular disease and related traits
- Dissecting the causal genetic mechanisms of coronary heart disease
- The CAA repeat polymorphism in the ZFHX3 gene is associated with risk of coronary heart disease in a Chinese population.
- Aging and cardiovascular diseases: the role of gene-diet interactions.
- Prediction of causal candidate genes in coronary artery disease loci
- Genetic study of complex diseases in the post-GWAS era.
- Genetics meets epigenetics: Genetic variants that modulate noncoding RNA in cardiovascular diseases.
- Gene expression signatures, pathways and networks in carotid atherosclerosis
- From locus association to mechanism of gene causality: the devil is in the details
- Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap
- The Lhx9-integrin pathway is essential for positioning of the proepicardial organ
- MiRNA-Related Polymorphisms in miR-146a and TCF21 Are Associated with Increased Susceptibility to Coronary Artery Disease in an Iranian Population
- From Loci to Biology: Functional Genomics of Genome-Wide Association for Coronary Disease
- Long Noncoding RNAs: From Clinical Genetics to Therapeutic Targets?
- A CRISPR Path to Engineering New Genetic Mouse Models for Cardiovascular Research
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