The inhibitory glycine receptor: a ligand-gated chloride channel of the central nervous system.
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Summary
The anion-conducting GlyR is established as a homolog of other ligand-gated ion channel proteins and suggest that the diversity of these channels originates from divergent evolution of a primordial channel protein early in phylogeny.
- Type
- review
- Published
- 1990-11-01
- Cited by
- 160
- References
- 60
- Access
- Open access
- OpenAlex
- https://openalex.org/W1964352423
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19898472
Keywords
Glycine receptor, Ligand-gated ion channel, Ion channel, Chloride channel, Cys-loop receptors
References
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- Identification of a glycine‐like fragment on the strychnine molecule
- Mouse spinal cord in cell culture. IV. Modulation of inhibitory synaptic function.
- The structure and mechanism of neurotransmitter receptors. Implications for the structure and function of the central nervous system.
- The glycine receptor deficiency of the mutant mouse spastic: evidence for normal glycine receptor structure and localization
- Three possible disulfides in the acetylcholine receptor alpha-subunit.
- Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes.
- Voltage-dependence of glycine-activated Cl- channels: a potentiometer for inhibition?
- Primary structure of a developmentally regulated nicotinic acetylcholine receptor protein from Drosophila
- Glycine receptor heterogeneity in rat spinal cord during postnatal development.
- Functional expression in Xenopus oocytes of the strychnine binding 48 kd subunit of the glycine receptor.
- Quaternary structure of the acetylcholine receptor
- Glycine vs GABA receptors
- Properties of human brain glycine receptors expressed in Xenopus oocytes
- Photoaffinity-labelling of the glycine receptor of rat spinal cord.
- Primary cultures of mouse spinal cord express the neonatal isoform of the inhibitory glycine receptor.
- Curious Facts in Molecular Physics
- Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer.
- Molecular biology of the GABAA receptor: the receptor/channel superfamily
- A quantitative description of membrane current and its application to conduction and excitation in nerve
Cited by
- Glycine receptors: heterogeneous and widespread in the mammalian brain.
- Mutations in the α1 subunit of the inhibitory glycine receptor cause the dominant neurologic disorder, hyperekplexia
- The localization of inhibitory neurotransmitter receptors on dopaminergic neurons of the human substantia nigra.
- Frontal lobe dysfunction in sporadic hyperekplexia
- Glutamate Transporter 1 in the Central Nervous System: Potential Target for the Treatment of Alcohol Dependence
- Recombinant glycine receptors: stoichiometry and kinetics
- Molecular design of oligomeric channel proteins.
- Molecular and cellular aspects of neurotransmission and neuromodulation.
- Ethanol-induced modulation of dopamine transmission and synaptic activity in striatal subregions - focus on inhibitory receptors
- Glycine‐gated chloride channels in neutrophils attenuate calcium influx and superoxide production
- Immunocytochemical localization of glycine receptors in the mammalian retina
- Ultrastructural basis for craniofacial sensory processing in the brainstem.
- Biology of the postsynaptic glycine receptor.
- Glycinergic synapses in the rod pathway of the rat retina: cone bipolar cells express the alpha 1 subunit of the glycine receptor
- Selective potentiation of alpha 1 glycine receptors by ginkgolic acid
- Comparative molecular physiology of novel P2X receptors : identification, cloning and functional characterisation
- Modulation of glycine receptor subunits and gephyrin expression in the rat facial nucleus after axotomy
- The anatomy of the vestibular nuclei.
- Inhibitory effects of corymine, an alkaloidal component from the leaves of Hunteria zeylanica, on glycine receptors expressed in Xenopus oocytes.
- Variation in the mitochondrial DNA of the Sylvilagus complex occupying the northeastern United States
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- Molecular tuning of fast gating in pentameric ligand-gated ion channels.
- The mammalian glycine receptor: biology and structure of a neuronal chloride channel protein.
- Mechanisms of channel gating of the ligand‐gated ion channel superfamily inferred from protein structure
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