The physiological structure of human C-reactive protein and its complex with phosphocholine.

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Summary

The structure shows how large ligands containing PC may be bound by CRP via a phosphate oxygen that projects away from the surface of the protein, inviting the design of inhibitors of CRP binding that may have therapeutic relevance to the possible role ofCRP in atherothrombotic events.

Type
article
Published
1999-02-15
Cited by
858
References
52
Access
Open access

Keywords

Phosphocholine, Protein subunit, Chemistry, Serum amyloid P component, Ligand (biochemistry)

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