The physiological structure of human C-reactive protein and its complex with phosphocholine.
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Summary
The structure shows how large ligands containing PC may be bound by CRP via a phosphate oxygen that projects away from the surface of the protein, inviting the design of inhibitors of CRP binding that may have therapeutic relevance to the possible role ofCRP in atherothrombotic events.
- Type
- article
- Published
- 1999-02-15
- Cited by
- 858
- References
- 52
- Access
- Open access
- OpenAlex
- https://openalex.org/W1964336741
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:37842374
Keywords
Phosphocholine, Protein subunit, Chemistry, Serum amyloid P component, Ligand (biochemistry)
References
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- Site-directed mutagenesis of the phosphocholine-binding site of human C-reactive protein: role of Thr76 and Trp67.
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- Samter's Immunologic Diseases
- Ca(2+)-dependent conformational change in synaptotagmin I.
- Two functionally different domains of rabphilin-3A, Rab3A p25/smg p25A-binding and phospholipid- and Ca(2+)-binding domains.
- Interaction of C-reactive protein complexes with the complement system. II. Consumption of guinea pig complement by CRP complexes: requirement for human C1q.
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- C-reactive protein reacts with the U1 small nuclear ribonucleoprotein.
- Localization of the phosphocholine-binding sites on C-reactive protein by immunoelectron microscopy.
- Lupus autoantibodies to native DNA cross-react with the A and D SnRNP polypeptides.
- Serum amyloid P component is the major calcium-dependent specific DNA binding protein of the serum.
- THE OCCURRENCE DURING ACUTE INFECTIONS OF A PROTEIN NOT NORMALLY PRESENT IN THE BLOOD
- PROCHECK: a program to check the stereochemical quality of protein structures
- Pentameric and decameric structures in solution of serum amyloid P component by X-ray and neutron scattering and molecular modelling analyses.
Cited by
- Evaluation of cardiovascular disease markers in patients submitted to carotid artery stenting or endarterectomy
- Biomarkers in the critically ill patient: C-reactive protein.
- Bioengineering the Expression of Active Recombinant Human Cathepsin G, Enteropeptidase, Neutrophil Elastase, and C-Reactive Protein in Yeast
- Bioanalytical solutions to characterize human proteome of clinical interest: healthy newborns and their early infections
- Rural medical schools and expansion of Australia's translational surgical research agenda
- Modulation of Systemic Immune Responses through Commensal Gastrointestinal Microbiota
- Multiple interactions of complement Factor H with its ligands in solution: a progress report.
- Sphingolipids and Ceramides of Mouse Aqueous Humor: Comparative Profiles from Normotensive and Hypertensive DBA/2J Mice
- Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites
- C1, SAP and ZiCo : structural studies of three metal‑binding proteins from a crystallographic perspective
- Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis.
- Regulation of C-reactive Protein Gene Expression and Function
- Mechanisms of the Anti-Pneumococcal Function of C-Reactive Protein
- Etude des effets de la protéine C-réactive sur certains aspects de la biologie des cellules mononucléées circulantes et des monocytes humains : Implications pour la physiopathologie des maladies cardiovasculaires
- Functional activities of C-reactive protein on neutrophils
- Mendelian randomisation and cardiovascular disease
- RISK STRATIFICATION OF BODY MASS INDEX
- Complement Factor H: solution structures and interactions with ligands
- Development and Validation of a Light Weight, Energy Dense, Ready to Eat (RTE) Bar
- Acute Phase Proteins in Animals
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