The Immunosuppressant FK506 Uncovers a Positive Regulatory Cross-talk between the Hog1p and Gcn2p Pathways*
Explore this paper's citation graph
Summary
It is demonstrated that both FK506-induced amino acid starvation and activation of the GCN pathway contribute to cell sensitivity to osmotic stress and reveal a positive regulatory loop between the Hog1p and Gcn2p pathways.
- Type
- article
- Published
- 2003-09-05
- Cited by
- 15
- References
- 64
- Access
- Open access
- OpenAlex
- https://openalex.org/W1963950954
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29409235
Keywords
Cell biology, Chemistry, Biology
References
- Osmotic Stress-Induced Gene Expression in Saccharomyces cerevisiae Requires Msn1p and the Novel Nuclear Factor Hot1p
- GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF‐2 alpha kinase GCN2 in amino acid‐starved cells.
- A novel and conserved salt‐induced protein is an important determinant of salt tolerance in yeast.
- Positive regulatory interactions of the HIS4 gene of Saccharomyces cerevisiae
- The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae
- Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control
- Evolution of osmotic stress signaling via MAP kinase cascades.
- The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease
- A novel eIF2B‐dependent mechanism of translational control in yeast as a response to fusel alcohols
- Rck2, a member of the calmodulin-protein kinase family, links protein synthesis to high osmolarity MAP kinase signaling in budding yeast
- Phytosphingosine as a Specific Inhibitor of Growth and Nutrient Import in Saccharomyces cerevisiae *
- Gcn2 Mediates Gcn4 Activation in Response to Glucose Stimulation or UV Radiation Not via GCN4 Translation*
- Methods in Enzymology, Vols. 350 and 351, Guide to Yeast Genetics and Molecular and Cell Biology, Parts B and C. Christine Guthrie and Gerald Fink, Eds. Academic Press, New York
- Drug target validation and identification of secondary drug target effects using DNA microarrays
- eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange.
- Transient Inhibition of Translation Initiation by Osmotic Stress*
- Translational Regulation of Yeast GCN4
- Risk for posttransplant Diabetes mellitus with current immunosuppressive medications.
- Association of GCN1–GCN20 regulatory complex with the N‐terminus of eIF2α kinase GCN2 is required for GCN2 activation
- Novel insights into the osmotic stress response of yeast.
Cited by
- FK506 sensitizes mammalian cells to high osmolarity by modulating p38 MAP kinase activation
- Amino acid catabolism: a pivotal regulator of innate and adaptive immunity
- Ascomycin and FK506: Pharmacology and Therapeutic Potential as Anticonvulsants and Neuroprotectants
- Nitrogen-dependent calcineurin activation in the yeast Hansenula polymorpha.
- ThHog1 controls the hyperosmotic stress response in Trichoderma harzianum.
- Dimerization Is Required for Activation of eIF2 Kinase Gcn2 in Response to Diverse Environmental Stress Conditions*
- Anti‐diabetic and anti‐obesity agent sodium tungstate enhances GCN pathway activation through Glc7p inhibition
- Gcn2p Regulates a G1/S Cell Cycle Checkpoint in Response to DNA Damage
- Miconazole Induces Changes in Actin Cytoskeleton prior to Reactive Oxygen Species Induction in Yeast*
- Translational regulation of GCN4 and the general amino acid control of yeast.
- Inappropriate translation inhibition and P-body formation cause cold-sensitivity in tryptophan-auxotroph yeast mutants.
- Effects of stress activated protein kinases on the expression of EST3 gene that encodes telomerase subunit in Saccharomyces cerevisiae
- Cyclosporin A but not FK506 activates the integrated stress response in human cells
- Gcn2 rescues reprogramming in the absence of Hog1/p38 signaling in C. neoformans during thermal stress
- Novel insights into the GCN2 pathway and its targeting. Therapeutic value in cancer and lessons from lung fibrosis development
- Ascomycin and FK506: Pharmacology and Therapeutic Potential as Anticonvulsants and Neuroprotectants
- Translational Regulation of GCN4 and the General Amino Acid Control
Related papers
- ФОРМИРОВAНИЕ ГОТОВНОСТИ БУДУЩИХ ПЕДAГОГОВ К ОРГAНИЗAЦИИ РAБОТЫ ПО РAЗВИТИЮ ВAЛЕОЛОГИЧЕСКОЙ КУЛЬТУРЫ ШКОЛЬНИКОВ
- A GEOMETRIC MEAN IN THE FURUTA INEQUALITY
- ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ
- Darstellung perhalogenierter Dimethyldisulfane durch photochemische Reaktion von CSF2 und CSFCI mit Sulfenylbromiden bzw. ‐chloriden
- Chemistry of geminal diazides. Rearrangements to N-Cyano compounds
- Reaktionen mit 3-Chloro-1,2-benzisothiazolium-chloriden. Synthese von 2-substituierten 3-Amino-benzo[b]-thiophenen