Interaction analysis of prenylated Rab GTPase with Rab escort protein and GDP dissociation inhibitor explains the need for both regulators

Keywords

Rab, Prenylation, GTPase, Geranylgeranylation, Effector

References

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• Fluorescence methods for monitoring interactions of Rab proteins with nucleotides, Rab escort protein, and geranylgeranyltransferase.Kirill Alexandrov, Axel J. Scheidig, Roger S. Goody — 2001
• Mechanism of Digeranylgeranylation of Rab ProteinsFang Shen, Miguel C. Seabra — 1996
• Regulation of reversible binding of smg p25A, a ras p21-like GTP-binding protein, to synaptic plasma membranes and vesicles by its specific regulatory protein, GDP dissociation inhibitor.Satoshi Araki, Akira Kikuchi, Y. Hata — 1990
• The structural and mechanistic basis for recycling of Rab proteins between membrane compartmentsRoger S. Goody, A. Rak, Kirill Alexandrov — 2005
• Protein Prenylation, et cetera--Signal Transduction in Two DimensionsMichael H. Gelb — 1997
• Moderate discrimination of REP‐1 between Rab7⋅GDP and Rab7⋅GTP arises from a difference of an order of magnitude in dissociation rates 1Kirill Alexandrov, Iris Simón, Andrei Iakovenko — 1998
• Characterization of the ternary complex between Rab7, REP-1 and Rab geranylgeranyl transferase.Kirill Alexandrov, Iris Simón, Vyacheslav Yurchenko — 1999
• Double Prenylation by RabGGTase Can Proceed without Dissociation of the Mono-prenylated Intermediate* 210Nicolas H. Thomä, Anca Niculae, Roger S. Goody — 2001
• Intein-mediated synthesis of geranylgeranylated Rab7 protein in vitro.Kirill Alexandrov, Ines Heinemann, Thomas Durek — 2002
• Synthesis of fluorescently labeled mono- and diprenylated Rab7 GTPase.Thomas Durek, Kirill Alexandrov, Roger S. Goody — 2004
• Binding of prenylated and polybasic peptides to membranes: affinities and intervesicle exchange.Farideh Ghomashchi, Xiaohong Zhang, Li Liu — 1995
• Synthesis and Application of Fluorescent Ras Proteins for Live‐Cell ImagingReinhard Reents, Mélanie Wagner, Stefanie Schlummer — 2005
• Yip3 catalyses the dissociation of endosomal Rab–GDI complexesUlf Sivars, Dikran Aivazian, Suzanne R. Pfeffer — 2003
• Photoaffinity analogues of farnesyl pyrophosphate transferable by protein farnesyl transferase.Kareem A. H. Chehade, Katarzyna Kiegiel, Richard Isaacs — 2002
• Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase.Olena Pylypenko, Alexey Rak, Reinhard Reents — 2003
• A Protein Fluorescence Amplifier: Continuous Fluorometric Assay for Rab GeranylgeranyltransferaseYao‐Wen Wu, Herbert Waldmann, Reinhard Reents — 2006
• Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids.Beatrice Dursina, Reinhard Reents, Christine Delon — 2006
• Expression of mammalian geranylgeranyltransferase type-II in Escherichia coli and its application for in vitro prenylation of Rab proteins.Alexandr Kalinin, Nicolas H. Thomä, Andrei Iakovenko — 2001
• Quantitative analysis of the interactions between prenyl Rab9, GDP dissociation inhibitor-alpha, and guanine nucleotidesAllan D. Shapiro, Suzanne R. Pfeffer — 1995

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• Posttranslational modifications of Rab proteins cause effective displacement of GDP dissociation inhibitor翁新楚, 段杉 — 2012
• Rab1a and Rab5a preferentially bind to binary lipid compositions with higher stored curvature elastic energyŽeljko Panian — 2013
• Rab GTPases and their interacting protein partners: Structural insights into Rab functional diversityM. I. Chibisov — 2017
• Membranlokalisation von Rab-Proteinen durch RabGEFsJulia Blümer, A. Itzen, R. Goody — 2013
• Biochemische Charakterisierung neuartiger GTPase aktivierender Proteine der Rho-Familie aus PflanzenAntje Schaefer, Alfred Wittinghofer — 2009
• Role of Rab7 in the pathogenesis of Charcot-Marie-Tooth Type2B (CMT2B) DiseaseSoumik Basuray — 2013
• Locking GTPases covalently in their functional statesDavid Luis Wiegandt, Sophie Vieweg, Frank T. Hofmann — 2015
• Analysis of coordinated skipped exon pairs using single molecule sequencing technologyAsa Adadey — 2014
• Assessment of functional characteristics of small GTPases using small moleculesJ. Agola — 2011
• Regulation of endocytosis and secretion by Rab GTPase activating proteinsAlexander K. Haas — 2008
• All About That Amide Bond: The 6th Chemical Protein Synthesis (CPS) MeetingCaroline E. Weller, Champak Chatterjee — 2015
• The small GTPase MoYpt7 is required for membrane fusion in autophagy and pathogenicity of Magnaporthe oryzae.Xiaohong Liu, Simiao Chen, Hui‐Min Gao — 2015
• Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes.Yao‐Wen Wu, Lena K. Oesterlin, Kui‐Thong Tan — 2010
• The role of the hypervariable C-terminal domain in Rab GTPases membrane targetingFu Li, Long Yi, Lei Zhao — 2014
• Rab10 GTPase regulates ER dynamics and morphologyAmber English, Gia K. Voeltz — 2012
• How not to do kinetics: examples involving GTPases and guanine nucleotide exchange factorsRoger S. Goody — 2014
• Regioselective Covalent Immobilization of Catalytically Active Glutathione S-Transferase on Glass SlidesRajesh Viswanathan, Guillermo R. Labadié, C. Dale Poulter — 2013
• Rab GTPase localization and Rab cascades in Golgi transportSuzanne R. Pfeffer — 2012
• A Structural Model of the GDP Dissociation Inhibitor Rab Membrane Extraction Mechanism*Alexander Ignatev, Sergey V. Kravchenko, Alexey Rak — 2008

Related papers

• Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate.Rudi Baron, Miguel C. Seabra — 2008
• Specific Prenylation of Tomato Rab Proteins by Geranylgeranyl Type-II Transferase Requires a Conserved Cysteine-Cysteine MotifShaul Yalovsky, Ann E. Loraine, Wilhelm Gruissem — 1996
• Synthesis of fluorescently labeled mono- and diprenylated Rab7 GTPase.Thomas Durek, Kirill Alexandrov, Roger S. Goody — 2004
• Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic diseaseJosé B. Pereira‐Leal, Alistair N. Hume, Miguel C. Seabra — 2001
• Intein‐Mediated Construction of a Library of Fluorescent Rab GTPase ProbesYao‐Wen Wu, Roger S. Goody, Kirill Alexandrov — 2011
• Prenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free systems but not in intact mammalian cells.Amy L. Wilson, Kathleen Sheridan, Robert Erdman — 1996
• Mechanism of Digeranylgeranylation of Rab ProteinsFang Shen, Miguel C. Seabra — 1996
• Structure of the Disordered C Terminus of Rab7 GTPase Induced by Binding to the Rab Geranylgeranyl Transferase Catalytic Complex Reveals the Mechanism of Rab Prenylation*Yao‐Wen Wu, Roger S. Goody, Ruben Abagyan — 2009
• Molecular Basis for Rab PrenylationChristelle Alory, William E. Balch — 2000