Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase*
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Summary
These paradigms are inadequate to account for GPCR-mediated, Ras-dependent activation of the mitogen-activated protein (MAP) kinases Erk1 and -2, and β2-adrenergic receptor-mediated activation of MAP kinase is inhibited in HEK293 cells expressing dominant suppressor mutants of β-arrestin or dynamin.
- Type
- article
- Published
- 1998-01-09
- Cited by
- 570
- References
- 28
- Access
- Open access
- OpenAlex
- https://openalex.org/W1963817582
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:32909724
Keywords
Endocytosis, Protein kinase A, Cell biology, Mitogen-activated protein kinase, Mitogen-activated protein kinase kinase
References
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- Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
- Protein kinases that phosphorylate activated G protein‐coupled receptors
- Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.
- Turning off the signal: desensitization of β‐adrenergic receptor function
- Raf meets Ras: completing the framework of a signal transduction pathway.
- Dynamin and β-Arrestin Reveal Distinct Mechanisms for G Protein-coupled Receptor Internalization*
- Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors
- Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis
- Dynamin, endocytosis and intracellular signalling (review).
- Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
- Receptor Up-regulation, Internalization, and Interconverting Receptor States
- The Role of Sequestration in G Protein-coupled Receptor Resensitization
- Thrombin Stimulates Phosphorylation of Insulin-like Growth Factor-1 Receptor, Insulin Receptor Substrate-1, and Phospholipase C-γ1 in Rat Aortic Smooth Muscle Cells (*)
- Phosphorylation of the Type 1A Angiotensin II Receptor by G Protein-coupled Receptor Kinases and Protein Kinase C*
- β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor
- Convergence of Angiotensin II and Platelet-derived Growth Factor Receptor Signaling Cascades in Vascular Smooth Muscle Cells (*)
- beta-Arrestin: a protein that regulates beta-adrenergic receptor function.
Cited by
- Heterómeros de receptores de dopamina. Nuevos mecanismos para la regulación de la transmisión dopaminérgica
- Phospholipase D and Its Product, Phosphatidic Acid, Mediate Agonist-dependent Raf-1 Translocation to the Plasma Membrane and the Activation of the Mitogen-activated Protein Kinase Pathway*
- Pharmacological importance of phospholipase D and phosphatidic acid in the regulation of the mitogen-activated protein kinase cascade.
- Agonist-dependent trafficking of alpha2-adrenoceptor subtypes: dependence on receptor subtype and employed agonist.
- Muscarinic receptor trafficking.
- Neuregulin-induced expression of the acetylcholine receptor requires endocytosis of ErbB receptors.
- Activation of p38 Mitogen-Activated Protein Kinase Promotes Epidermal Growth Factor Receptor Internalization
- Arrestin-2 and G Protein-coupled Receptor Kinase 5 Interact with NFκB1 p105 and Negatively Regulate Lipopolysaccharide-stimulated ERK1/2 Activation in Macrophages*
- A novel seven-helix transmembrane protein BTP1 of Botrytis cinerea controls the expression of GST-encoding genes, but is not essential for pathogenicity.
- H-ras resides on clathrin-independent ARF6 vesicles that harbor little RAF-1, but not on clathrin-dependent endosomes.
- β‐Arrestin‐kinase scaffolds: turn them on or turn them off?
- Temporal cAMP Signaling Selectivity by Natural and Synthetic MC4R Agonists.
- TENASCIN CYTOTACTIN EGF-LIKE REPEATS - NOVEL MATRIKINE LIGANDS FOR THE EPIDERMAL GROWTH FACTOR RECEPTOR
- Basic aspects of acquired immunity : Dendritic cells and T cells in motion
- G protein-coupled receptor signalling and cross-talk: achieving rapidity and specificity.
- Kappa opioid receptor regulation of ERK1 /2 MAP kinase signaling cascade: Molecular mechanisms modulating cocaine reward
- Beta-Adrenergic, Arachidonic Acid and Potassium Channel Associated-Regulation of Human Breast Cancer Cell Lines
- The PDZ adaptor protein, NHERF1, organizes and regulates protein complexes at the cell membrane
- Melanocortin 5 receptor signaling pathways: implications on adipocyte biology.
- Interrelaciones moleculares y funcionales entre receptores de dopamina, cannabinoides y adenosina en el estriado
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