Pharmacokinetic properties of 2'-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats.
Explore this paper's citation graph
Summary
A balance of greater stability supplied by the 2'-O-MOE modification together with maintenance of plasma protein binding appears to be necessary to ensure favorable pharmacokinetics of this new generation of antisense oligonucleotides.
- Type
- article
- Published
- 2001-03-01
- Cited by
- 284
- References
- 42
- OpenAlex
- https://openalex.org/W1961577685
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11597182
Keywords
Pharmacokinetics, Oligonucleotide, Chemistry, Biodistribution, Excretion
References
- In Vivo Metabolic Profile of a Phosphorothioate Oligodeoxyribonucleotide
- Phosphorothioate oligonucleotides inhibit the intrinsic tenase complex.
- Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding.
- Inhibition of endothelial cell adhesion molecule expression with antisense oligonucleotides.
- Pharmacokinetics and metabolism in mice of a phosphorothioate oligonucleotide antisense inhibitor of C-raf-1 kinase expression.
- Pharmacokinetic properties of several novel oligonucleotide analogs in mice.
- In vivo distribution and metabolism of a phosphorothioate oligonucleotide within rat liver after intravenous administration.
- Biodistribution and metabolism of internally 3H-labeled oligonucleotides. I. Comparison of a phosphodiester and a phosphorothioate.
- Transcellular metabolism of leukotrienes and regulation of cardiac function
- On-line HPLC electrospray mass spectrometry of phosphorothioate oligonucleotide metabolites.
- Absorption of Antisense Oligonucleotides in Rat Intestine: Effect of Chemistry and Length
- Comparative Pharmacokinetics, Tissue Distribution, and Tumor Accumulation of Phosphorothioate, Phosphorodithioate, and Methylphosphonate Oligonucleotides in Nude Mice
- A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides.
- 2'-carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation.
- Evidence for a concentration-dependent polymerization of a commercial human serum albumin.
- Quantitation of phosphorothioate oligonucleotides in human plasma.
- EFFECTS OF INTRAVENOUS INFUSION OF PHOSPHOROTHIOATE OLIGONUCLEOTIDES ON COAGULATION, COMPLEMENT ACTIVATION AND HEMODYNAMICS
- Tritium labeling of antisense oligonucleotides by exchange with tritiated water.
- Measurement of Macromolecular Binding Using Electrospray Mass Spectrometry. Determination of Dissociation Constants for Oligonucleotide: Serum Albumin Complexes
- Pharmacokinetics, metabolism, and elimination of a 20-mer phosphorothioate oligodeoxynucleotide (CGP 69846A) after intravenous and subcutaneous administration.
Cited by
- Pharmacokinetics and biodistribution of phosphorodiamidate morpholino antisense oligomers.
- Influence of diverse chemical modifications on the ADME characteristics and toxicology of antisense oligonucleotides
- RNA helicase A is not required for RISC activity.
- Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier
- Phosphorothioates, Essential Components of Therapeutic Oligonucleotides
- Enhancing the Therapeutic Delivery of Oligonucleotides by Chemical Modification and Nanoparticle Encapsulation
- Silençage du gène ApoB codant pour l’apolipoprotéine B responsable de l’athérosclérose, in vitro et in vivo, à l’aide des nanoparticules chitosane/siARN-ApoB
- Antisense therapies for cancer: Bridging the pharmacogenomic divide
- Antisense oligonucleotides, microRNAs, and antibodies.
- Nano-siRNA Particles and Combination Therapies for Ovarian Tumor Targeting
- Radiolabelled Oligonucleotides for Evaluation of in vivo Hybridisation Utilising PET Methodology
- The emperor's new dystrophin: finding sense in the noise.
- Nanotechnologies and controlled release systems for the delivery of antisense oligonucleotides and small interfering RNA
- Thermodynamics and kinetics of antisense oligonucleotide hybridization to a structured mRNA target
- A Novel Long Non-Coding RNA Transcript Regulates The Fate of Colon Cancer Initiation
- Antisense oligonucleotides against TNFR1 prevent toxicity of TNF/IFNγ treatment in mouse tumor models
- Application of RNAi to cancer research and therapy.
- On the mechanism of cationic lipid-mediated delivery of oligonucleotides: towards an antisense therapy
- Dose-Dependent Pharmacokinetic Profiles of 2′-O-Methyl Phosphorothioate Antisense Oligonucleotidesin mdx Mice
- Polymeric Systems for Transscleral Delivery of Antisense Oligonucleotides: A Novel Treatment Strategy for Age-Related Macular Degeneration
Related papers
- Biodistribution and metabolism of internally 3H-labeled oligonucleotides. II. 3',5'-blocked oligonucleotides.
- Polyethyleneimine-mediated transfection to improve antisense activity of 3'-capped phosphodiester oligonucleotides.
- Replacement of the Phosphodiester Linkage in Oligonucleotides by a C==C Double Bond: Comparison of the cis and trans Isomers
- A convenient solid phase approach to obtain lipophilic 5′-phosphoramidate derivatives of DNA and RNA oligonucleotides
- Promotion of stable triplex formation by partial incorporation of 2',5'-phosphodiester linkages into triplex-forming oligonucleotides.
- Biodistribution of phosphodiester and phosphorothioate siRNA.
- Effect of G-rich sequences on the synthesis, purification, hybridization, cell uptake, and hemolytic activity of oligonucleotides
- Kinetic analysis of the cleavage of natural and synthetic substrates by the Serratia nuclease.
- Replacement of the phosphodiester linkage in oligonucleotides by a C=C double bond: Comparison of the cis and trans isomers
- Hybridization of Alternating Cationic/Anionic Oligonucleotides to RNA Segments