Regulation of translation via TOR signaling: insights from Drosophila melanogaster.
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Summary
Recent data obtained by genetic studies in the fruit fly Drosophila melanogaster demonstrate the importance of both insulin-like signaling and TOR signaling in promoting growth and identified a major downstream target of TOR and insulin- like signaling as the translational machinery.
- Type
- review
- Published
- 2001-11-01
- Cited by
- 34
- References
- 57
- Access
- Open access
- OpenAlex
- https://openalex.org/W1957087401
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4509363
Keywords
Drosophila melanogaster, TOR signaling, Biology, Cell biology, Signal transduction
References
- Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F
- The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential.
- Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice
- Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB
- The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila
- The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
- PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development.
- Constitutive activation of S6 kinase by deletion of amino-terminal autoinhibitory and rapamycin sensitivity domains
- The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease
- Purification and Characterization of a New Eukaryotic Protein Translation Factor
- eIF4G--A Multipurpose Ribosome Adapter?
- Drosophila S6 kinase: a regulator of cell size.
- Regulation of eIF-4E BP1 Phosphorylation by mTOR*
- Genetic analysis of protein kinase B (AKT) in Drosophila.
- Further Biochemical and Kinetic Characterization of Human Eukaryotic Initiation Factor 4H*
- The Drosophila insulin receptor is required for normal growth.
- Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways.
- Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism*
- An MBoC Favorite: TOR controls translation initiation and early G1 progression in yeast
- Phosphorylation of eukaryotic protein synthesis initiation factors.
Cited by
- METABOLIC ENGINEERING OF EUKARYOTIC SIGNAL TRANSDUCTION IN DROSOPHILA SCHNEIDER 2 (S2) CELL CULTURE
- Impact of rapamycin on chronological life span of filamentous fungi
- Regulation of the Mammalian Target Of Rapamycin Complex 2 (mTORC2)
- Neuroendocrine system in lifespan control of Drosophila melanogaster
- Role of insulin-like signalling in Drosophila lifespan.
- Vascular endothelial growth factor induces protein synthesis in renal epithelial cells: a potential role in diabetic nephropathy.
- Mechanisms regulating nutrition-dependent developmental plasticity through organ-specific effects in insects
- Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway.
- Age-Specific Variation in Immune Response in Drosophila melanogaster Has a Genetic Basis
- Specific roles of Target of rapamycin in the control of stem cells and their progeny in the Drosophila ovary
- Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery
- Altering Drosophila S6 kinase activity is consistent with a role for S6 kinase in growth
- A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy.
- Understanding at the molecular level the consequences of defective ATR signalling in humans
- The Drosophila Poly(A) Binding Protein-Interacting Protein, dPaip2, Is a Novel Effector of Cell Growth
- Programmed Cell Death 4 (PDCD4): A Novel Player in Ethanol Mediated Suppression of Protein Translation in Primary Cortical Neurons and Developing Cerebral Cortex
- mTORC1‐ and mTORC2‐interacting proteins keep their multifunctional partners focused
- Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells.
- The regulation of growth by nitric oxide signalling in "Drosophila melanogaster".
- Induction of Autophagy and Apoptosis via PI3K/AKT/TOR Pathways by Azadirachtin A in Spodoptera litura Cells
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