SSR240612 [(2R)-2-[((3R)-3-(1,3-Benzodioxol-5-yl)-3-[(6-methoxy-2-naphthyl)sulfonyl]aminopropanoyl)amino]-3-(4-[2R,6S)-2,6-dimethylpiperidinyl]methylphenyl)-N-isopropyl-N-methylpropanamide Hydrochloride], a New Nonpeptide Antagonist of the Bradykinin B1 Receptor: Biochemical and Pharmacological
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Summary
SSR240612 is a new, potent, and orally active specific non-peptide bradykinin B1 receptor antagonist that inhibited thermal hyperalgesia induced by UV irradiation and prevented neuropathic thermal pain induced by sciatic nerve constriction in the rat.
- Type
- article
- Published
- 2004-05-01
- Cited by
- 113
- References
- 30
- OpenAlex
- https://openalex.org/W1956547950
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23825294
Keywords
Chemistry, Receptor, Bradykinin, Sulfonyl, Molecular biology
References
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Cited by
- Small molecule bradykinin B1 receptor antagonists as potential therapeutic agents for pain.
- Angiotensin-(1-7) Augments Endothelium-dependent Relaxations of Porcine Coronary Arteries to Bradykinin by Inhibiting Angiotensin-Converting Enzyme 1
- Beneficial effects of kinin B1 receptor antagonism on plasma fatty acid alterations and obesity in Zucker diabetic fatty rats.
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- Development of a mouse model for the study of osteoarthritis pain
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- Antinociceptive Pharmacology of N-[[4-(4,5-Dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[[(4-methoxy-2,6-dimethylphenyl) sulfonyl]methylamino]ethoxy]-N-methylacetamide, Fumarate (LF22-0542), a Novel Nonpeptidic Bradykinin B1 Receptor Antagonist
- Effects of kinin B1 and B2 receptor antagonists on overactive urinary bladder syndrome induced by spinal cord injury in rats
- A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5
- A possible common pharmacophore in the non-peptide antagonists of the bradykinin B1 receptor.
- The kallikrein-kinin system: current and future pharmacological targets.
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