The Nucleotide-Binding Oligomerization Domain-Like Receptor NLRC5 Is Involved in IFN-Dependent Antiviral Immune Responses
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Summary
It is concluded that NLRC5 may represent a molecular switch of IFN-γ activation sequence/IFN-specific response element signaling pathways contributing to antiviral defense mechanisms.
- Type
- article
- Published
- 2010-01-08
- Cited by
- 210
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W1952767463
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:207421274
Keywords
Biology, Cell biology, Gene knockdown, Signal transduction, Downregulation and upregulation
References
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- CARD15 mutations in Blau syndrome
- A fever gene comes in from the cold
- Regulation of IFN‐α/β genes: evidence for a dual function of the transcription factor complex ISGF3 in the production and action of IFN‐α/β
- Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
- A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
- Regulation of Interferon-Induced Protein Kinase PKR: Modulation of P58IPK Inhibitory Function by a Novel Protein, P52rIPK
- The microbial and danger signals that activate Nod-like receptors.
- NLRX1 is a regulator of mitochondrial antiviral immunity
- Regulation of JAK–STAT signalling in the immune system
- Function of Nod-like Receptors in Microbial Recognition and Host Defense
- NALP1 in vitiligo-associated multiple autoimmune disease.
- CARD15 mutations in familial granulomatosis syndromes: a study of the original Blau syndrome kindred and other families with large-vessel arteritis and cranial neuropathy.
- Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan.
- JAK-STAT Signaling: From Interferons to Cytokines*
- Gout-associated uric acid crystals activate the NALP3 inflammasome
- An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid
- The CATERPILLER family: an ancient family of immune/apoptotic proteins.
- The NOD: a signaling module that regulates apoptosis and host defense against pathogens
- Mechanisms of type-I- and type-II-interferon-mediated signalling
Cited by
- A Role for the Human Nucleotide-binding Domain, Leucine-rich Repeat-containing Family Member NLRC5 in Antiviral Responses*
- A mutation in the NLRC5 promoter limits NF-κB signaling after Salmonella Enteritidis infection in the spleen of young chickens.
- Plasma Pattern Recognition Receptors of Walleye (Sander vitreus M.) with an Emphasis on Mannose-binding Lectin-Like Protein and Viral Hemorrhagic Septicemia Virus
- Regulation of the Proteasome: Evaluating the Lung Proteasome as a New Therapeutic Target
- Respiratory Syncytial Virus Infection Upregulates NLRC5 and Major Histocompatibility Complex Class I Expression through RIG-I Induction in Airway Epithelial Cells
- Characterization of NLR-A subfamily members in miiuy croaker and comparative genomics revealed NLRX1 underwent duplication and lose in actinopterygii.
- B‐cell‐activating factor code and human cytomegalovirus infection in renal transplant recipients
- Cutting Edge: NLRC5-Dependent Activation of the Inflammasome
- NLRC5 Deficiency Selectively Impairs MHC Class I- Dependent Lymphocyte Killing by Cytotoxic T Cells
- NLRC5 interacts with RIG-I to induce a robust antiviral response against influenza virus infection
- Correction: Functional Analysis of Chicken IRF7 in Response to dsRNA Analog Poly(I:C) by Integrating Overexpression and Knockdown
- NLRC5: a key regulator of MHC class I-dependent immune responses
- Enhanced TLR-induced NF-κB signaling and type I interferon responses in NLRC5 deficient mice
- Induction and function of virus-specific CD4+ T cell responses
- Regulation of immune pathways by the NOD-like receptor NLRC5
- NLRC5 knockdown in chicken macrophages alters response to LPS and poly (I:C) stimulation
- Buying Time—The Immune System Determinants of the Incubation Period to Respiratory Viruses
- NLRC5 Mediates Cytokine Secretion in RAW264.7 Macrophages and Modulated by the JAK2/STAT3 Pathway
- The Expanding Role of NLRs in Antiviral Immunity
- The Tiers and Dimensions of Evasion of the Type I Interferon Response by Human Cytomegalovirus
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