Most B cells that have switched surface immunoglobulin isotypes generate clones of cells that do not secrete IgM.
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Summary
It is suggested that isotype switching is generally irreversible, and isotypes are expressed in a 5'- to -3' direction that is consistent with the germline gene order.
- Type
- article
- Published
- 1981-09-01
- Cited by
- 16
- References
- 0
- Access
- Open access
- OpenAlex
- https://openalex.org/W1949742151
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23606639
Keywords
Immunoglobulin D, Isotype, Phosphorylcholine, Molecular biology, Surface Immunoglobulin
References
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Cited by
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- Spontaneous Immunoglobulin Class Switching in Myeloma and Hybridoma Cell Lines Differs from Physiological Class Switching
- Human b-cell differentiation. I. Analysis of immunoglobulin heavy chain switching using monoclonal anti-immunoglobulin M, G, and A antibodies and pokeweed mitogen-induced plasma cell differentiation
- Immunosuppression caused by antigen feeding II. Suppressor T cells mask Peyer's patch B cell priming to orally administered antigen
- Quality of antibodies secreted by clones in microcultures from B cells enriched on haptenated gelatin: isotypes and avidities.
- Effect of TH-lines and clones on the growth and differentiation of B cell clones in microculture.
- IgA COMMITMENT: MODELS FOR B‐CELL DIFFERENTIATION AND POSSIBLE ROLES FOR T‐CELLS IN REGULATING B‐CELL DEVELOPMENT *
- B‐Lymphoproliferative disorders: A Proposed unified pathogenetic pathway
- Isotype‐Specific T Cell Regulation of Immunoglobulin Expression
- Patterns of isotype expression by B cell clones responding to thymus‐dependent and thymus‐independent antigens in vitro
- Relationship between expression of IgA by Peyer's patch cells and functional IgA memory cells
- Chemical synthesis and immunological evaluation of entirely carbohydrate conjugate Globo H-PS A1
- Rearrangement of RAG-1 recombinase gene in radiation-sensitive ``wasted`` mice
- Rearrangement of RAG- 1
- Analysis of Immunoglobulin Changes in Lymphoproliferative Diseases
- 13 – Peyer's Patches as Inductive Sites for IgA Commitment
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