Most B cells that have switched surface immunoglobulin isotypes generate clones of cells that do not secrete IgM.

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Summary

It is suggested that isotype switching is generally irreversible, and isotypes are expressed in a 5'- to -3' direction that is consistent with the germline gene order.

Type
article
Published
1981-09-01
Cited by
16
References
0
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Open access

Keywords

Immunoglobulin D, Isotype, Phosphorylcholine, Molecular biology, Surface Immunoglobulin

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