Negative and positive regulation in trans of gene expression from adeno-associated virus vectors in mammalian cells by a viral rep gene product
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Summary
It is shown that trans-acting negative or positive regulation of gene expression by the AAV rep gene is modulated by factors in the host cell and by the helper adenovirus.
- Type
- article
- Published
- 1986-08-01
- Cited by
- 162
- References
- 65
- Access
- Open access
- OpenAlex
- https://openalex.org/W1949194573
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27129457
Keywords
Biology, Gene product, Chloramphenicol acetyltransferase, Molecular biology, Transfection
References
- An adenovirus type 5 early gene function regulates expression of other early viral genes.
- Characterization of a "silencer" in yeast: a DNA sequence with properties opposite to those of a transcriptional enhancer.
- Enhancers and eukaryotic gene expression
- Genetic analysis of adeno-associated virus: properties of deletion mutants constructed in vitro and evidence for an adeno-associated virus replication function
- Mapping of the 5' termini of two adeno-associated virus 2 RNAs in the left half of the genome
- Effect of deletions in adenovirus early region 1 genes upon replication of adeno-associated virus
- Molecular cloning of adeno-associated virus variant genomes and generation of infectious virus by recombination in mammalian cells.
- Replication of adeno-associated virus DNA. Complementation of naturally occurring rep- mutants by a wild-type genome or an ori- mutant and correction of terminal palindrome deletions.
- Nucleotide sequence and organization of the adeno-associated virus 2 genome
- Expression of recombinant genes containing herpes simplex virus delayed-early and immediate-early regulatory regions and trans activation by herpesvirus infection
- A human parvovirus, adeno-associated virus, as a eucaryotic vector: transient expression and encapsidation of the procaryotic gene for chloramphenicol acetyltransferase
- Adeno-associated virus vector for high-frequency integration, expression, and rescue of genes in mammalian cells
- Integration of the adeno-associated virus genome into cellular DNA in latently infected human Detroit 6 cells
- Genetics of adeno-associated virus: isolation and preliminary characterization of adeno-associated virus type 2 mutants
- Transcriptional activation and subsequent control of the human heat shock gene during adenovirus infection
- Evidence for a direct role for both the 175,000- and 110,000-molecular-weight immediate-early proteins of herpes simplex virus in the transactivation of delayed-early promoters
- trans-Activation of parvovirus P38 promoter by the 76K noncapsid protein
- Transcriptional activation of cloned human beta-globin genes by viral immediate-early gene products.
- Cloning of adeno-associated virus into pBR322: rescue of intact virus from the recombinant plasmid in human cells.
- Adenovirus E1a proteins repress transcription from the SV40 early promoter.
Cited by
- Differential neuropeptide Y gene expression in post-mitotic versus dividing neuroblastoma cells driven by an adeno-associated virus vector.
- The Adeno-Associated Virus Type 2 Regulatory Proteins Rep78 and Rep68 Interact with the Transcriptional Coactivator PC4
- A Chimeric Protein Containing the N Terminus of the Adeno-Associated Virus Rep Protein Recognizes Its Target Site in an In Vivo Assay
- Production and Purification of Highly Replication Defective HSV-1 Based Gene Therapy Vectors
- Packaging systems for adeno-associated virus vectors.
- Use of adeno-associated virus as a general transduction vector for mammalian cells.
- Viral Expression Vectors
- Sequences required for coordinate induction of adeno-associated virus p19 and p40 promoters by Rep protein
- Regulated expression of the feline panleukopenia virus P38 promoter on extrachromosomal FPV/EBV chimeric plasmids
- Expression of Aleutian mink disease parvovirus proteins in a baculovirus vector system
- Interaction of the adeno-associated virus Rep protein with a sequence within the A palindrome of the viral terminal repeat
- The adeno-associated virus rep gene suppresses herpes simplex virus-induced DNA amplification
- Efficient gene transfer with adeno-associated virus-based plasmids complexed to cationic liposomes for gene therapy of human prostate cancer.
- Evidence for covalent attachment of the adeno-associated virus (AAV) rep protein to the ends of the AAV genome
- Infecções respiratórias por bocavirus humano: aspectos clínicos e moleculares
- Determination and analysis of the complete nucleotide sequence of human herpesvirus
- Parvovirus replication in normal and transformed human cells correlates with the nuclear translocation of the early protein NS1
- Sequence requirements for binding of Rep68 to the adeno-associated virus terminal repeats
- Novel transcription map for the B19 (human) pathogenic parvovirus
- Autonomous parvovirus and densovirus gene vectors.
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