Upregulation of C-C chemokine receptor type 7 expression by membrane-associated prostaglandin E synthase-1/prostaglandin E2 requires glycogen synthase kinase 3β-mediated signal transduction in colon cancer cells.
Explore this paper's citation graph
Summary
Results showed that mPGES‑1‑dependent release of PGE2 was markedly induced in colon cancer cells after transient transfection with mPGes‑1 overexpression vector, accompanied by elevated CCR7 expression, and EP4 antagonists and AKT/GSK-3β inhibitors may emerge as potential therapeutics to reduce CCR 7 expression in coloncancer.
- Type
- article
- Published
- 2015-11-01
- Cited by
- 6
- References
- 19
- Access
- Open access
- OpenAlex
- https://openalex.org/W1948949985
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9222800
Keywords
Cancer research, C-C chemokine receptor type 7, GSK-3, GSK3B, Glycogen synthase
References
- An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.
- Functional organization of secondary lymphoid organs by the chemokine system.
- CCR7‐mediated migration in the thymus controls γδ T‐cell development
- Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation.
- Cancer: Inflammation lights the way to metastasis
- Prostaglandin E2 produced by inducible COX-2 and mPGES-1 promoting cancer cell proliferation in vitro and in vivo.
- Tumor cells induce COX-2 and mPGES-1 expression in microvascular endothelial cells mainly by means of IL-1 receptor activation.
- Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice.
- Identification and development of mPGES-1 inhibitors: where we are at?
- Detection of Active Fraction of Glycogen Synthase Kinase 3β in Cancer Cells by Nonradioisotopic in vitro Kinase Assay
- COX-2, mPGES-1 and EP2 receptor immunohistochemical expression in canine and feline malignant mammary tumours.
- Microvascular COX-2/mPGES-1/EP-4 axis in human abdominal aortic aneurysm
- Differential Requirement For CCR4 and CCR7 During The Development of Innate and Adaptive αβT-cells In The Adult Thymus
- Involvement of chemokine receptors in breast cancer metastasis
- Statins Enhance Rotator Cuff Healing by Stimulating the COX2/PGE2/EP4 Pathway
- Membrane Prostaglandin E Synthase-1: A Novel Therapeutic Target
- A critical role of CCR7 in invasiveness and metastasis of SW620 colon cancer cell in vitro and in vivo
Cited by
- EpCAM and COX‑2 expression are positively correlated in human breast cancer.
- Maternal exposure to prostaglandin E2 modifies expression of Wnt genes in mouse brain – An autism connection
- Assessment of AKT/mTOR Signaling Pathway Components in Kidney Cancers and Their Connection with Metastases
- C-C Chemokine Receptor 7 in Cancer
- SM Journal of Hematology and Oncology
- Integrative In Silico and FFPE Tissue Analyses Elucidate Upregulated Genes in Colorectal Cancer Enriched for Tie2-Expressing Macrophages/Monocytes
Related papers
- In Vivo Evidence in the Brain for Lithium Inhibition of Glycogen Synthase Kinase-3
- GSK‐3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and β‐catenin stabilisation without elevation of glycogen synthase activity
- Glycogen synthase kinase 3: more than a namesake
- Multisite phosphorylation of glycogen synthase from rabbit skeletal muscle
- Glycogen Synthase Kinase-3β in Formation and Treatment of Parkinson's Disease
- Erythropoietin inhibits cardiomyocyte apoptosis through inactivation of glycogen synthase kinase 3β
- Role of glycogen synthase kinase-3 in the pathogenesis of Alzheimer's disease
- Expression and characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity in intact cells.