Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways
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Summary
The results suggested that the unusual capacity of MERS-CoV to infect T cells and induce apoptosis might partly contribute to the high pathogenicity of the virus.
- Type
- article
- Published
- 2015-07-22
- Cited by
- 418
- References
- 51
- Access
- Open access
- OpenAlex
- https://openalex.org/W1947409115
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:36144703
Keywords
Biology, Spleen, Apoptosis, Middle East respiratory syndrome coronavirus, Pathogenesis
References
- Development and Evaluation of Novel Real-Time Reverse Transcription-PCR Assays with Locked Nucleic Acid Probes Targeting Leader Sequences of Human-Pathogenic Coronaviruses
- Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012.
- Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset
- CD26-mediated signaling for T cell activation occurs in lipid rafts through its association with CD45RO
- Distinct Immune Response in Two MERS-CoV-Infected Patients: Can We Go from Bench to Bedside?
- Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment.
- Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets
- Executioner Caspase-3, -6, and -7 Perform Distinct, Non-redundant Roles during the Demolition Phase of Apoptosis*
- Bilateral Entry and Release of Middle East Respiratory Syndrome Coronavirus Induces Profound Apoptosis of Human Bronchial Epithelial Cells
- Infection with MERS-CoV Causes Lethal Pneumonia in the Common Marmoset
- Middle East Respiratory Syndrome Coronavirus Accessory Protein 4a Is a Type I Interferon Antagonist
- T Cell Responses Are Required for Protection from Clinical Disease and for Virus Clearance in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice
- Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study
- Apoptosis: A Review of Programmed Cell Death
- Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques
- Cell Host Response to Infection with Novel Human Coronavirus EMC Predicts Potential Antivirals and Important Differences with SARS Coronavirus
- Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus
- Coronavirus as a possible cause of severe acute respiratory syndrome
- Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response
- Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease.
Cited by
- CD8+ T Cells and Macrophages Regulate Pathogenesis in a Mouse Model of Middle East Respiratory Syndrome
- The celecoxib derivative kinase inhibitor AR-12 (OSU-03012) inhibits Zika virus via down-regulation of the PI3K/Akt pathway and protects Zika virus-infected A129 mice: A host-targeting treatment strategy
- Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset
- Middle East respiratory syndrome coronavirus infection: virus-host cell interactions and implications on pathogenesis
- Dipeptidyl Peptidase 4 Distribution in the Human Respiratory Tract
- Coronaviruses — drug discovery and therapeutic options
- Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome
- Value of Autopsy Emphasized in the Case Report of a Single Patient with Middle East Respiratory Syndrome
- Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus
- Virus-host interactions of emerging respiratory pathogens
- Middle East Respiratory Syndrome: Emergence of a Pathogenic Human Coronavirus.
- Viral RNA in Blood as Indicator of Severe Outcome in Middle East Respiratory Syndrome Coronavirus Infection
- Predictive factors for pneumonia development and progression to respiratory failure in MERS-CoV infected patients
- Human Coronaviruses: A Review of Virus–Host Interactions
- MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2
- Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 Is an Important Surface Attachment Factor That Facilitates Entry of Middle East Respiratory Syndrome Coronavirus
- Molecular Basis of Coronavirus Virulence and Vaccine Development
- T-cell immunity of SARS-CoV: Implications for vaccine development against MERS-CoV
- Middle east respiratory syndrome corona virus spike glycoprotein suppresses macrophage responses via DPP4-mediated induction of IRAK-M and PPARγ
- Effective inhibition of MERS-CoV infection by resveratrol
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