Microtubule depolymerization inhibits transport of cathepsin D from the Golgi apparatus to lysosomes.
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Summary
The results suggest that efficient transport of cathepsin D from the Golgi apparatus to a prelysosomal compartment and lysosomes is facilitated by microtubules and the spatial organization of these organelles.
- Type
- article
- Published
- 1990-08-01
- Cited by
- 47
- References
- 45
- OpenAlex
- https://openalex.org/W1946178771
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24786337
Keywords
Nocodazole, Golgi apparatus, Microtubule, Cell biology, Biology
References
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- Biosynthesis and transport of cathepsin D in cultured human fibroblasts
- Microtubules, membrane traffic, and cell organization.
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- Selective recycling of the mannose 6-phosphate/IGF-II receptor to the trans Golgi network in vitro.
- Tubular lysosome morphology and distribution within macrophages depend on the integrity of cytoplasmic microtubules.
Cited by
- Cytoskeletal architecture and cathepsin B trafficking in human articular chondrocytes
- Wechselwirkungen von Proteinen mit der cytoplasmatischen Domäne des 46-kDa-Mannose-6-Phosphat-Rezeptors bei Rattus norvegicus (Berkenhout, 1796)
- Intracellular Traffic of Herpes Simplex Virus Glycoprotein gE: Characterization of the Sorting Signals Required for Itstrans-Golgi Network Localization
- Trafficking-deficient hERG K⁺ channels linked to long QT syndrome are regulated by a microtubule-dependent quality control compartment in the ER.
- Modulation of phenotypic expression of fibroblasts by alteration of the cytoskeleton
- Human NRAMP2/DMT1, Which Mediates Iron Transport across Endosomal Membranes, Is Localized to Late Endosomes and Lysosomes in HEp-2 Cells*
- Microtubule-associated Protein-dependent Binding of Phagosomes to Microtubules (*)
- The role of microtubule-based motor proteins in maintaining the structure and function of the Golgi complex.
- From Lysosomes to the Plasma Membrane
- Slow intracellular trafficking of catalase nanoparticles targeted to ICAM-1 protects endothelial cells from oxidative stress.
- Role of monocytes in cryoglobulinemia-associated nephritis.
- How to get to the right place at the right time: Rab/Ypt small GTPases and vesicle transport
- Microtubule independent vesiculation of Golgi membranes and the reassembly of vesicles into Golgi stacks
- Golgi-associated GSK3β regulates the sorting process of post-Golgi membrane trafficking
- Ethanol consumption alters trafficking of lysosomal enzymes and affects the processing of procathepsin L in rat liver.
- West Nile Virus Infection Causes Endocytosis of a Specific Subset of Tight Junction Membrane Proteins
- Caveolin cycles between plasma membrane caveolae and the Golgi complex by microtubule-dependent and microtubule-independent steps
- Confocal scanning laser microscopy of the follicular epithelium in ovarioles of the stick insect Carausius morosus
- The Alzheimer amyloid precursor is associated with the detergent- insoluble cytoskeleton
- Drug‐induced alterations in rat peritubular cell cytoskeleton result in proteoglycan synthesis modifications. Comparison with some intracellular signaling pathways
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