Horizontal spread of synchronized activity in neocortex and its control by GABA-mediated inhibition.
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Summary
The horizontal spread of normal cortical activity is strongly constrained by GABAA-mediated IPSPs, a relatively small reduction in the efficacy of inhibition leads to a large increase in the spread of excitation, and the character of epileptiform activity is strong affected by the influences of inhibition.
- Type
- article
- Published
- 1989-04-01
- Cited by
- 538
- References
- 37
- OpenAlex
- https://openalex.org/W1944684909
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20366712
Keywords
Bicuculline, GABAA receptor, Neocortex, Inhibitory postsynaptic potential, Postsynaptic potential
References
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- PRESYNAPTIC ACTIONS OF β‐AMINOBUTYRIC ACID AND SOME ANTAGONISTS IN A SLICE PREPARATION OF CUNEATE NUCLEUS
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- GABA, Bicuculline and Central Inhibition
- Spontaneous Rhythmic Synchronous Activity in Epileptic Human and Normal Monkey Temporal Lobe
- Long-term potentiation and NMDA receptors in rat visual cortex
- Retrograde transport of gamma-amino[3H]butyric acid reveals specific interlaminar connections in the striate cortex of monkey.
- Lateral spread of neuronal activity within the motor cortex investigated with intracellular responses to distant epicortical stimulation.
- Epileptogenesis in neocortical slices.
- Inhibitory control of local excitatory circuits in the guinea‐pig hippocampus.
Cited by
- Damage, Reorganization, and Abnormal Neocortical Hyperexcitability in the Pilocarpine Model of Temporal Lobe Epilepsy
- Spatial distribution of long-term potentiation in the surround of visual cortex lesions in vitro
- Intracortical modulation of somatosensory evoked fields during movement: evidence for selective suppression of postsynaptic inhibition.
- Neocortical focus: experimental view.
- NORMAL AND DISEASED CIRCUITRY IN THE CEREBELLAR AND CEREBRAL CORTEX
- Seizures and epilepsy
- Nicotinic and muscarinic activation of motoneurons in the crayfish locomotor network.
- Conducting polymer devices for biolectronics
- Intracortical processes regulating the integration of sensory information.
- Waves and Oscillations in Model Neuronal Networks
- Mechanisms of inhibition and neuronal integration for signal processing in the primary auditory cortex of the Mongolian gerbil (Meriones unguiculatus)
- Spike-wave complexes and fast components of cortically generated seizures. II. Extra- and intracellular patterns.
- Network Activity in Neurons of the Motor and Prefrontal Areas of the Cortex in Trained Cats in Conditions of Systemic Administration of m-Cholinoreceptor Blockers
- An Exploration of the Role of Cellular Neuroplasticity in Large Scale Models of Biological Neural Networks
- Functional alterations in GABAergic inhibition during activity.
- Molecular and cellular aspects of neurotransmission and neuromodulation.
- Age-Dependent Effects Of Chronic GABAA Receptor Blockade In Barrel Cortex
- Synchronization in dynamic neural networks
- Seizures and Epilepsy
- Central Auditory Processing and Neural Modeling
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