Amitriptyline to relieve pain in juvenile idiopathic arthritis: a pilot study using Bayesian metaanalysis of multiple N-of-1 clinical trials.
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Summary
It is unlikely that amitriptyline reduced pain by a clinically significant amount in these children with polyarticular JIA, but Bayesian techniques were used successfully to obtain estimates of population effect, despite the small number of participants.
- Type
- article
- Published
- 2007-05-01
- Cited by
- 46
- References
- 46
- OpenAlex
- https://openalex.org/W1943785122
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25990712
Keywords
Medicine, Amitriptyline, Placebo, Population, Credible interval
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- Drugs for chronic pain in children: a commentary on clinical practice and the absence of evidence.
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- Reporting of core items in hierarchical Bayesian analysis for aggregating N-of-1 trials to estimate population treatment effects is suboptimal.
- The Essential Guide to N-of-1 Trials in Health
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