The Latent Herpes Simplex Virus Type 1 Genome Copy Number in Individual Neurons Is Virus Strain Specific and Correlates with Reactivation
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Summary
This is the first demonstration that the number of HSV genome copies within individual latently infected neurons is regulated by viral genetic factors, and suggests that the latent genome copy number may be an important parameter for subsequent induced reactivation in vivo.
- Type
- article
- Published
- 1998-07-01
- Cited by
- 201
- References
- 37
- Access
- Open access
- OpenAlex
- https://openalex.org/W1942310387
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22428042
Keywords
Biology, Herpes simplex virus, Virus latency, Virology, Genome
References
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- Comprehensive quantification of herpes simplex virus latency at the single-cell level
Cited by
- Induction of E6/E7 expression in cottontail rabbit papillomavirus latency following UV activation.
- Neuronal latency in human and animal herpesvirus infections.
- Wide Variations in Herpes Simplex Virus Type 1 Inoculum Dose and Latency-Associated Transcript Expression Phenotype Do Not Alter the Establishment of Latency in the Rabbit Eye Model
- An investigation into the existence of cyprinid herpesvirus-3 encoded microRNAs
- The presence of latent virus influences the maintenance and phenotype of the HSV-specific CD8 memory population
- CD4 T cells are both protective and pathologic in mice following ocular herpes simplex virus type 1 (HSV-1) infection
- The role of dendritic cells in the cornea in the adaptive immune response following Herpes Simplex Virus-1 ocular infection
- Application of a nanoflare probe specific to a latency associated transcript for isolation of KHV latently infected cells
- Molecular characterisation of the Herpes Simplex Virus-1 LATP2 enhancer region.
- UL12 and ICP0 Regulate DNA Repair Pathway Choice During HSV-1 Infection
- [Herpes simplex virus type 1 latency and reactivation: an update].
- Efectos neuropatológicos de la infección hematógena por el virus Herpes Simplex de tipo 1 en un modelo de envejecimiento en ratones
- Lack of Interleukin-6 (IL-6) Enhances Susceptibility to Infection but Does Not Alter Latency or Reactivation of Herpes Simplex Virus Type 1 in IL-6 Knockout Mice
- HSV-1 migration in latently infected and naive rabbits after penetrating keratoplasty.
- Functions of the latency-related gene (LR gene) of bovine herpesvirus type 1 (BoHV-1) and other proteins expresed during latency.
- Ectopic expression of DNA encoding IFN-alpha 1 in the cornea protects mice from herpes simplex virus type 1-induced encephalitis.
- Detection of feline herpes virus 1 via polymerase chain reaction and immunohistochemistry in cats with ulcerative facial dermatitis, eosinophilic granuloma complex reaction patterns and mosquito bite hypersensitivity.
- Preparation of Single Cells from Solid Tissues for Analysis by PCR
- A comparison of herpes simplex virus type 1 and varicella-zoster virus latency and reactivation.
- Inflation and Long-Term Maintenance of CD8 T-Cells Responding to a Latent Herpesvirus Depend upon Establishment of Latency and Presence of Viral Antigens
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