Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity
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Summary
The results suggest that the large TSP1 molecule employs at least two different structural domains and perhaps two different mechanisms to accomplish a single physiological function, the inhibition of neovascularization.
- Type
- article
- Published
- 1993-07-02
- Cited by
- 581
- References
- 92
- Access
- Open access
- OpenAlex
- https://openalex.org/W1941829554
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1470686
Keywords
Angiogenesis, In vivo, Procollagen peptidase, Thrombospondin 1, Molecular biology
References
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- Isolation and characterization of a heparin-binding domain from the amino terminus of platelet thrombospondin.
- COMP (cartilage oligomeric matrix protein) is structurally related to the thrombospondins.
- Human dermal microvascular endothelial but not human umbilical vein endothelial cells express CD36 in vivo and in vitro.
Cited by
- Thrombospondins: from structure to therapeutics
- Angiogenesis: models and modulators.
- Suppression of thrombospondin 1 and 2 production by herpes simplex virus 1 infection in cultured keratocytes.
- Bovine Thrombospondin-2: Complete Complementary Deoxyribonucleic Acid Sequence and Immunolocalization in the External Zones of the Adrenal Cortex.
- Matrix metalloproteinases: pro- and anti-angiogenic activities.
- Shear stress modulates the expression of thrombospondin-1 and CD36 in endothelial cells in vitro and during shear stress-induced angiogenesis in vivo.
- A Phase II Study of ABT-510 (Thrombospondin-1 Analog) for the Treatment of Metastatic Melanoma
- Breast Cyst Fluid Plasmin Activity and Its Effect on TGF-β2 Activation
- The hemostatic system in angiogenesis.
- Angiogenesis: a Dynamic Balance of Stimulators and Inhibitors
- Untersuchungen zur antiangiogenen Aktivität des matrizellulären Proteins Thrombospondin-2
- Cell density regulates thrombospondin-1 production in malignant glioma cells
- Endogenous Regulators of Angiogenesis – Emphasis on Proteins with Thrombospondin – Type I Motifs
- Angiogenesis and angiogenesis inhibition: an overview.
- Binding and displacement of vascular endothelial growth factor (VEGF) by thrombospondin: Effect on human microvascular endothelial cell proliferation and angiogenesis
- Endogenous angiogenesis inhibitors: angiostatin, endostatin, and other proteolytic fragments.
- In vitro and in vivo systems to assess role of C-X-C chemokines in regulation of angiogenesis.
- The role of growth factors in vascular cell development and differentiation.
- Aberrant production of interleukin-8 and thrombospondin-1 by psoriatic keratinocytes mediates angiogenesis.
- A novel antiangiogenic peptide derived from hepatocyte growth factor inhibits neovascularization in vitro and in vivo
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