Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons
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Summary
It is discovered that the modulatory peptide neurotensin can induce a persistent synaptic depression by decreasing dopamine release, a synaptic mechanism that could contribute to addiction and/or schizophrenia.
- Type
- article
- Published
- 2015-08-05
- Cited by
- 26
- References
- 58
- Access
- Open access
- OpenAlex
- https://openalex.org/W1937444857
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:30464448
Keywords
Autoreceptor, Dopamine, Dopaminergic, Neurotransmission, Neuroscience
References
- Additions and Corrections to The Caenorhabditis elegans small GTP-binding protein RhoA is enriched in the nerve ring and sensory neurons during larval development.
- Structure, Functional Expression, and Cerebral Localization of the Levocabastine-Sensitive Neurotensin/Neuromedin N Receptor from Mouse Brain
- Protein kinase C mediates neurotensin inhibition of inwardly rectifying potassium currents in rat substantia nigra dopaminergic neurons.
- Neurotensin: a new 'reward peptide'.
- Neurotensin: Topographical distribution in rat brain by immunohistochemistry
- Behavioral and neurochemical effects of neurotensin microinjection into the ventral tegmental area of the rat.
- Calcium-dependent release of somatostatin and neurotensin from rat brain in vitro
- Somatodendritic release of endogenous dopamine: in vivo dialysis in the A10 dopamine region.
- Correspondence between high affinity 125I‐neurotensin binding sites and dopaminergic neurons in the rat substantia nigra and ventral tegmental area: A combined radioautographic and immunohistochemical light microscopic study
- The electrophysiological actions of neurotensin in the central nervous system.
- Calcium Regulation of Calcineurin Phosphatase Activity by Its B Subunit and Calmodulin
- The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse?
- Reversal of Dopamine Inhibition of Dopaminergic Neurons of the Ventral Tegmental Area is Mediated by Protein Kinase C
- Repeated activation of neurotensin receptors sensitizes to the stimulant effect of amphetamine.
- Cannabinoids activate mesolimbic dopamine neurons by an action on cannabinoid CB1 receptors.
- Neurotensin afferents of the ventral tegmental area in the rat: [1] re‐examination of their origins and [2] responses to acute psychostimulant and antipsychotic drug administration
- Neurotensin potentiates the potassium-induced release of endogenous dopamine from rat striatal slices.
- Endogenous Neurotensin in the Ventral Tegmental Area Contributes to Amphetamine Behavioral Sensitization
- Reversal of Dopamine D2 Agonist-Induced Inhibition of Ventral Tegmental Area Neurons by Gq-Linked Neurotransmitters Is Dependent on Protein Kinase C, G Protein-Coupled Receptor Kinase, and Dynamin
- Synapsins as regulators of neurotransmitter release.
Cited by
- Antagonism of Neurotensin Receptors in the Ventral Tegmental Area Decreases Methamphetamine Self-Administration and Methamphetamine Seeking in Mice
- The Emerging Roles of the Calcineurin-Nuclear Factor of Activated T-Lymphocytes Pathway in Nervous System Functions and Diseases
- Neurotensin Receptor-1 Identifies a Subset of Ventral Tegmental Dopamine Neurons that Coordinate Energy Balance
- Neurotensin speeds inhibition of dopamine neurons through temporal modulation of GABAA and GABAB receptor-mediated synaptic input
- Diverse actions of the modulatory peptide neurotensin on central synaptic transmission
- Regulation of Ventral Tegmental Area Dopamine Neuron Activity by Feeding-related Hypothalamic Neuropeptides
- Acute and subchronic PCP attenuate D2 autoreceptor signaling in substantia nigra dopamine neurons
- Diversity in the lateral hypothalamic input to the ventral tegmental area.
- Neurotensin receptors inhibit mGluR I responses in nigral dopaminergic neurons via a process that undergoes functional desensitization by G-protein coupled receptor kinases.
- Neurotensin receptor 1 deletion suppresses methamphetamine self-administration and the associated reduction in dopamine cell firing
- Neurotensin receptor 1 deletion decreases methamphetamine self-administration and the associated reduction in dopamine cell firing
- Dopamine D2 autoreceptor interactome: targeting the receptor complex as a strategy for treatment of substance use disorder
- Depression of substantia nigra dopamine transmission is driven by retrograde neurotensin release and is enhanced by methamphetamine self-administration
- Activation of Ventral Tegmental Area Neurotensin Receptor-1 Neurons Promotes Weight Loss
- Unraveiling the correlation among neurodevelopmental and inflammatory biomarkers in patients with chronic schizophrenia
- Applying a Fast-Scan Cyclic Voltammetry to Explore Dopamine Dynamics in Animal Models of Neuropsychiatric Disorders
- Effects of age and sex on dendritic D2 autoreceptor inhibition in substantia nigra dopamine neurons
- Preservation of dendritic D2 receptor transmission in substantia nigra dopamine neurons with age
- Neurotensin receptor 1-biased ligand attenuates neurotensin-mediated excitation of ventral tegmental area dopamine neurons and dopamine release in the nucleus accumbens
- Deregulation of NF-κB associated long non-coding RNAs in bipolar disorder
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