Adeno‐associated virus‐mediated expression of acid sphingomyelinase decreases atherosclerotic lesion formation in apolipoprotein E−/− mice
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Summary
This study aimed to determine whether the level of circulating ASM activity affects lesion development in mouse model of atherosclerosis.
- Type
- article
- Published
- 2011-06-01
- Cited by
- 19
- References
- 30
- OpenAlex
- https://openalex.org/W1935835548
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20286584
Keywords
Acid sphingomyelinase, Lesion, Apolipoprotein E, Apolipoprotein B, Sphingomyelin
References
- Sphingomyelinase Induces Aggregation and Fusion of Small Very Low–Density Lipoprotein and Intermediate-Density Lipoprotein Particles and Increases Their Retention to Human Arterial Proteoglycans
- Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix. A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation.
- Sequential ultracentrifugation micromethod for separation of serum lipoproteins and assays of lipids, apolipoproteins, and lipoprotein particles.
- The response-to-retention hypothesis of early atherogenesis.
- Secretory Sphingomyelinase, a Product of the Acid Sphingomyelinase Gene, Can Hydrolyze Atherogenic Lipoproteins at Neutral pH
- The Cellular Trafficking and Zinc Dependence of Secretory and Lysosomal Sphingomyelinase, Two Products of the Acid Sphingomyelinase Gene*
- AAV8-mediated hepatic expression of acid sphingomyelinase corrects the metabolic defect in the visceral organs of a mouse model of Niemann-Pick disease.
- Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase.
- Lipolysis of LDL by Human Secretory Phospholipase A2 Induces Particle Fusion and Enhances the Retention of LDL to Human Aortic Proteoglycans
- Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: a possible link between inflammatory cytokines and atherogenesis.
- Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins.
- Roles and Regulation of Secretory and Lysosomal Acid Sphingomyelinase
- Role of secretory phospholipases in atherogenesis
- Macrophage released proteoglycans are involved in cell-mediated aggregation of LDL.
- Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry.
- Scaleable chromatographic purification process for recombinant adeno‐associated virus (rAAV)
- Sphingolipidomics: high-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry.
- Sphingomyelinases: their regulation and roles in cardiovascular pathophysiology.
- Human Vascular Endothelial Cells Are a Rich and Regulatable Source of Secretory Sphingomyelinase
- Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis.
Cited by
- Autophagy in Vascular Disease
- Enzymatic Targets in Atherosclerosis
- Sphingolipids and atherosclerosis.
- Secretory sphingomyelinase in health and disease
- The emerging role of Acid Sphingomyelinase in autophagy
- Rutaecarpine suppresses atherosclerosis in ApoE−/− mice through upregulating ABCA1 and SR-BI within RCT[S]
- Control of Autophagy Maturation by Acid Sphingomyelinase in Mouse Coronary Arterial Smooth Muscle Cells: Protective Role in Atherosclerosis
- AAV2/8-hSMAD3 gene delivery attenuates aortic atherogenesis, enhances Th2 response without fibrosis, in LDLR-KO mice on high cholesterol diet
- Crystal structure of mammalian acid sphingomyelinase
- Progression of atherosclerosis in ApoE-knockout mice fed on a high-fat diet.
- SIRT1 activator E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.
- nSMase2 (Type 2-Neutral Sphingomyelinase) Deficiency or Inhibition by GW4869 Reduces Inflammation and Atherosclerosis in Apoe−/− Mice
- Contribution of p62/SQSTM1 to PDGF-BB-induced myofibroblast-like phenotypic transition in vascular smooth muscle cells lacking Smpd1 gene
- Contribution of acid sphingomyelinase to angiotensin II‐induced vascular adventitial remodeling via membrane rafts/Nox2 signal pathway
- Potential therapeutic targets for atherosclerosis in sphingolipid metabolism
- Acid sphingomyelinase promotes SGK1-dependent vascular calcification
- Desipramine enhances the stability of atherosclerotic plaque in rabbits monitored with molecular imaging
- The therapeutic potential of sphingolipids for cardiovascular diseases
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