Microvesicles from platelets: novel drivers of vascular inflammation
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Summary
The various aspects of platelet-derived microvesicles including release, clearance, measurement, occurrence during disease and relevance for the pathophysiology of vascular inflammation will be discussed.
- Type
- review
- Published
- 2015-05-21
- Cited by
- 103
- References
- 127
- Access
- Open access
- OpenAlex
- https://openalex.org/W1935158033
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:32537259
Keywords
Microvesicles, Platelet, Inflammation, Immune system, Immunology
References
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- CD40 ligand+ microparticles from human atherosclerotic plaques stimulate endothelial proliferation and angiogenesis a potential mechanism for intraplaque neovascularization.
- CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
- Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules.
- Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. Studies in Scott syndrome: an isolated defect in platelet procoagulant activity.
- Platelet-derived microparticle formation involves glycoprotein IIb-IIIa. Inhibition by RGDS and a Glanzmann's thrombasthenia defect.
- Standardization of platelet‐derived microparticle enumeration by flow cytometry with calibrated beads: results of the International Society on Thrombosis and Haemostasis SSC Collaborative workshop
- Cell-derived Microparticles Circulate in Healthy Humans and Support Low Grade Thrombin Generation
- Aging- and activation-induced platelet microparticles suppress apoptosis in monocytic cells and differentially signal to proinflammatory mediator release.
- Circulating activated platelets assist THP-1 monocytoid/endothelial cell interaction under shear stress.
- Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
- Modulation of monocyte-endothelial cell interactions by platelet microparticles.
- Microparticles from apoptotic platelets promote resident macrophage differentiation
- Increased levels of microparticles originating from endothelial cells, platelets and erythrocytes in subjects with metabolic syndrome: relationship with oxidative stress.
- Cellular origins and thrombogenic activity of microparticles isolated from human atherosclerotic plaques.
Cited by
- Microparticle and Atherothrombotic Diseases.
- The role of platelets in inflammation
- Extracellular vesicles as mediators of vascular inflammation in kidney disease.
- Microparticles as new markers of cardiovascular risk in diabetes and beyond
- The Effect of Antiplatelet Medications on Innate Immune Activation
- The prowess of platelets in immunity and inflammation
- Platelet function in baboons and humans - A comparative study of whole blood using impedance platelet aggregometry (Multiplate®).
- Super-Resolution Microscopy: The Dawn of a New Era in Cardiovascular Research
- Cell-Derived Microparticles in Patients with Type 2 Diabetes Mellitus: a Systematic Review and Meta-Analysis
- Effects of purified anthocyanin supplementation on platelet chemokines in hypocholesterolemic individuals: a randomized controlled trial
- Novel Risk Markers and Risk Assessments for Cardiovascular Disease
- Mechanisms of Endothelial Activation in Sepsis and Cell Culture Models to Study the Heterogeneous Host Response
- Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype
- Endothelial vascular markers in coronary surgery
- Flow cytometer optimisation and standardisation for the study of extracellular vesicles as translational biomarkers
- Lactobacillus casei BL23 Produces Microvesicles Carrying Proteins That Have Been Associated with Its Probiotic Effect
- Standardization of a fast and effective method for the generation and detection of platelet-derived microparticles by a flow cytometer.
- Platelet-derived microparticles analysis: Techniques, challenges and recommendations.
- Procoagulant Effects of Low-Level Platelet Activation and Its Inhibition by Colchicine
- A proteomic approach reveals the variation in human platelet protein composition after storage at different temperatures
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