An Outbreak of Human Coronavirus OC43 Infection and Serological Cross-reactivity with SARS Coronavirus.
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Summary
Findings underscore the virulence of human CoV-OC43 in elderly populations and confirm that cross-reactivity to antibody against nucleocapsid proteins from these viruses must be considered when interpreting serological tests for SARS-CoV.
- Type
- article
- Published
- 2006-11-01
- Cited by
- 165
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W1933155703
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26655969
Keywords
Serology, Virology, Coronavirus, Outbreak, Pneumonia
References
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- Cross-reactivity of antibody against SARS-coronavirus nucleocapsid protein with IL-11
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- Comprehensive detection and identification of human coronaviruses, including the SARS-associated coronavirus, with a single RT-PCR assay
- Profiles of IgG Antibodies to Nucleocapsid and Spike Proteins of the SARS-Associated Coronavirus in SARS Patients
- SARS--looking back over the first 100 days.
- Sequence analysis of the N, P, M and F genes of Canadian human metapneumovirus strains
- Antigenic Cross-Reactivity between Severe Acute Respiratory Syndrome—Associated Coronavirus and Human Coronaviruses 229E and OC43
- Manual of Clinical Microbiology
- Transmission Dynamics of the Etiological Agent of SARS in Hong Kong: Impact of Public Health Interventions
- Human coronavirus OC43 causes influenza-like illness in residents and staff of aged-care facilities in Melbourne, Australia
- Identification of severe acute respiratory syndrome in Canada.
- Investigation of a nosocomial outbreak of severe acute respiratory syndrome (SARS) in Toronto, Canada.
- A novel coronavirus associated with severe acute respiratory syndrome.
- Serological Responses in Patients with Severe Acute Respiratory Syndrome Coronavirus Infection and Cross-Reactivity with Human Coronaviruses 229E, OC43, and NL63
- Identification of a novel coronavirus in patients with severe acute respiratory syndrome.
- False-Positive Results in a Recombinant Severe Acute Respiratory Syndrome-Associated Coronavirus (SARS-CoV) Nucleocapsid-Based Western Blot Assay Were Rectified by the Use of Two Subunits (S1 and S2) of Spike for Detection of Antibody to SARS-CoV
Cited by
- The Human Coronavirus Nucleocapsid Protein and Its Effects on the Innate Immune Response
- Guidelines for the management of adult lower respiratory tract infections--summary.
- EXPRESSION OF HUMAN CORONAVIRUS NL63 AND SARS-CoV NUCLEOCAPSID PROTEINS FOR ANTIBODY PRODUCTION
- Molecular Determinants of Severe Acute Respiratory Syndrome Coronavirus Pathogenesis and Virulence in Young and Aged Mouse Models of Human Disease
- Immunoreactivity characterisation of the three structural regions of the human coronavirus OC43 nucleocapsid protein by Western blot: Implications for the diagnosis of coronavirus infection
- Development of a recombinant truncated nucleocapsid protein based immunoassay for detection of antibodies against human coronavirus OC43
- Human Coronavirus OC43 Nucleocapsid Protein Binds MicroRNA 9 and Potentiates NF-κB Activation
- Severe Acute Respiratory Syndrome–Associated Coronavirus Infection in Toronto Children: A Second Look
- Epidemiology and Clinical Presentations of the Four Human Coronaviruses 229E, HKU1, NL63, and OC43 Detected over 3 Years Using a Novel Multiplex Real-Time PCR Method
- Severity and Outcome Associated With Human Coronavirus OC43 Infections Among Children
- Epidemiological and clinical features of human coronavirus infections among different subsets of patients
- Serological assays for emerging coronaviruses: Challenges and pitfalls
- Guidelines for the management of adult lower respiratory tract infections - Full version
- Molecular Epidemiology of Human Coronavirus OC43 Reveals Evolution of Different Genotypes over Time and Recent Emergence of a Novel Genotype due to Natural Recombination
- Systematic Assembly of a Full-Length Infectious Clone of Human Coronavirus NL63
- Development of a Nucleocapsid-Based Human Coronavirus Immunoassay and Estimates of Individuals Exposed to Coronavirus in a U.S. Metropolitan Population
- Recombination, Reservoirs, and the Modular Spike: Mechanisms of Coronavirus Cross-Species Transmission
- Host-pathogen interactions during coronavirus infection of primary alveolar epithelial cells
- Mechanisms of Severe Acute Respiratory Syndrome Pathogenesis and Innate Immunomodulation
- A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong
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