Neural plasticity in pancreatitis and pancreatic cancer
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Summary
Novel possibilities for mechanistically uncovering the role of the nervous system in pancreatic disease progression are discussed, as demonstrated by tissue and neural damage inducing neuropathic pain, and activated neurons releasing mediators that modulate inflammation and cancer growth.
- Type
- review
- Published
- 2015-11-01
- Cited by
- 232
- References
- 109
- OpenAlex
- https://openalex.org/W1931605118
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12197440
Keywords
Pancreatic cancer, Medicine, Pancreatitis, Cancer, Nervous system
References
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Cited by
- Progression of Structural Brain Changes in Patients With Chronic Pancreatitis and Its Association to Chronic Pain: A 7-Year Longitudinal Follow-up Study
- New insights into perineural invasion of pancreatic cancer: More than pain.
- Sleeping in on pancreatic cancer pain: Schwann cell secreted IL-6 pushes snooze on the pain alarm
- Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities
- Continuous Low-dose-rate Irradiation of Iodine-125 Seeds Inhibiting Perineural Invasion in Pancreatic Cancer
- AAPT Diagnostic Criteria for Chronic Cancer Pain Conditions
- Can Stopping Nerves, Stop Cancer?
- Early pancreatic cancer lesions suppress pain through CXCL12-mediated chemoattraction of Schwann cells
- Upregulation of RET induces perineurial invasion of pancreatic adenocarcinoma
- Neuroplasticity of Supraspinal Structures Associated with Pathological Pain
- Nerve Dependence: From Regeneration to Cancer.
- Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment
- The autonomic nervous system and cancer
- Modelling pain associated with pancreatic ductal adenocarcinoma in mice.
- Pleiotrophin and N-syndecan promote perineural invasion and tumor progression in an orthotopic mouse model of pancreatic cancer
- PAP/REG3A favors perineural invasion in pancreatic adenocarcinoma and serves as a prognostic marker
- MRI assessed pancreatic morphology and exocrine function are associated with disease burden in chronic pancreatitis
- Characterization of Pancreatic Morphology and Function With Advanced MRI: a study in patiens with chronic Pancreatis and healthy controls
- Inflammatory monocytes promote perineural invasion via CCL2-mediated recruitment and cathepsin B expression
- Towards a neurobiological understanding of pain in chronic pancreatitis: mechanisms and implications for treatment
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