Degradation of the interferon-induced 68,000-M(r) protein kinase by poliovirus requires RNA

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Summary

A hypothetical model depicting possible mechanisms of P68 degradation in poliovirus-infected cells is presented and it is found that preincubation of cell extracts with the synthetic dsRNA poly(I-C) largely prevented P68 proteolysis, providing additional evidence for the critical role of RNA.

Type
article
Published
1993-02-01
Cited by
89
References
81
Access
Open access

Keywords

Biology, Proteolysis, RNA, Proteases, Molecular biology

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